The regulation of integrin function by divalent cations
文献类型：期刊论文
| 作者 | Zhang, K; Chen, JF |
| 刊名 | CELL ADHESION & MIGRATION
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:1页码:20-29 |
| 关键词 | integrin divalent cations affinity MIDAS ADMIDAS SyMBS |
| 通讯作者 | Chen, JF (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Shanghai, Peoples R China.,jfchen@sibs.ac.cn |
| 英文摘要 | Integrins are a family of alpha/beta heterodimeric adhesion metallo-protein receptors and their functions are highly dependent on and regulated by different divalent cations. Recently advanced studies have revolutionized our perception of integrin metal ion-binding sites and their specific functions. Ligand binding to integrins is bridged by a divalent cation bound at the MIDAS motif on top of either alpha I domain in I domain-containing integrins or beta I domain in alpha I domain-less integrins. The MIDAS motif in beta I domain is flanked by ADMIDAS and SyMBS, the other two crucial metal ion binding sites playing pivotal roles in the regulation of integrin affinity and bidirectional signaling across the plasma membrane. The beta-propeller domain of alpha subunit contains three or four beta-hairpin loop-like Ca2+-binding motifs that have essential roles in integrin biogenesis. The function of another Ca2+-binding motif located at the genu of alpha subunit remains elusive. Here, we provide an overview of the integrin metal ion-binding sites and discuss their roles in the regulation of integrin functions. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | PLATELET GLYCOPROTEIN-IIB ; CALCIUM-BINDING DOMAINS ; FUNCTION-ASSOCIATED ANTIGEN-1 ; SITE-DIRECTED MUTAGENESIS ; AMINO-ACID SUBSTITUTION ; METAL-ION BINDING ; I-LIKE DOMAIN ; LIGAND-BINDING ; CELL-ADHESION ; A-DOMAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304611500005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/532]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, K,Chen, JF. The regulation of integrin function by divalent cations[J]. CELL ADHESION & MIGRATION,2012,6(1):20-29. |
| APA | Zhang, K,&Chen, JF.(2012).The regulation of integrin function by divalent cations.CELL ADHESION & MIGRATION,6(1),20-29. |
| MLA | Zhang, K,et al."The regulation of integrin function by divalent cations".CELL ADHESION & MIGRATION 6.1(2012):20-29. |
入库方式： OAI收割
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