UXT-V1 Facilitates the Formation of MAVS Antiviral Signalosome on Mitochondria
文献类型：期刊论文
| 作者 | Huang, YF; Liu, H; Ge, R; Zhou, Y; Lou, XW; Wang, C |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 188期号:1页码:358-366 |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,cwang01@sibs.ac.cn |
| 英文摘要 | Virus infection induces the MAVS-TNFR-associated factor (TRAF) 3 signaling axis on mitochondria. It remains to elucidate the corresponding regulatory processes. In this study, we identify UXT-V1 as a novel TRAF3-binding protein. UXT-V1 is critical for the virus-induced activation of NF-kappa B and IFN regulatory factor 3. Reduction of UXT-V1 impairs the induction of IFN-beta and attenuates the host antiviral responses. The N-terminal TRAF-binding motif of UXT-V1 binds to the C-terminal TRAF domain of TRAF3, thus facilitating the interaction between TRAF3 and MAVS. Notably, TRAF3 and TNFR-associated death domain protein are recruited onto mitochondria upon virus infection. These translocations are blocked when knocking down UXT-V1. Thus, UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction. The Journal of Immunology, 2012, 188: 358-366. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | TOLL-LIKE RECEPTORS ; NF-KAPPA-B ; ADAPTER PROTEIN ; INNATE IMMUNITY ; TRAF3 ; RECOGNITION ; ACTIVATION ; RESPONSES ; VIRUS ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000298628400042 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/537]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, YF,Liu, H,Ge, R,et al. UXT-V1 Facilitates the Formation of MAVS Antiviral Signalosome on Mitochondria[J]. JOURNAL OF IMMUNOLOGY,2012,188(1):358-366. |
| APA | Huang, YF,Liu, H,Ge, R,Zhou, Y,Lou, XW,&Wang, C.(2012).UXT-V1 Facilitates the Formation of MAVS Antiviral Signalosome on Mitochondria.JOURNAL OF IMMUNOLOGY,188(1),358-366. |
| MLA | Huang, YF,et al."UXT-V1 Facilitates the Formation of MAVS Antiviral Signalosome on Mitochondria".JOURNAL OF IMMUNOLOGY 188.1(2012):358-366. |
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