Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
文献类型：期刊论文
| 作者 | Zhao, G; Chen, YY; Qin, GW; Guo, LH |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:1页码:176-186 |
| 关键词 | Antioxidation Hydrogen peroxide Luteolin Neuroprotectant Oxidant-antioxidant balance Reactive oxygen species |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,zhaogangtcm@hotmail.com ; lhguo@sibs.ac.cn |
| 英文摘要 | Increased attention has been paid to the role of oxidant/antioxidant imbalance in neurodegenerative process and pharmaceutical neuroprotective interventions. Food-derived compound luteolin possesses multitarget actions including reactive oxygen species (ROS)-scavenging activity in cultured human endothelial cells or permanent immature rat oligodendrocytes. This study aims to elucidate whether luteolin has a neuroprotective tendency toward ROS-insulted neural cells. The present results showed that luteolin, isolated from the ripe seed of Perilla frutescens (L.) Britt., markedly reversed hydrogen peroxide-induced cytotoxicity in primary culture cortical neurons but not in cultured human neuroblastoma cells. Upon the ROS-insulted primary neurons, luteolin concentration-dependently enhanced neuronal cell survival with efficacy higher than and potency similar to vitamin E. Additionally, luteolin significantly attenuated the increase in ROS production and prevented the decreases in activities of mitochondria, catalase, and glutathione in ROS-insulted primary neurons. Thus, luteolin functions by neuroprotection possibly through a rebalancing of pro-oxidant-antioxidant status. This agent points to possible interventions for preventing neurodegenerative diseases such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease, as well as for improving brain aging. (C) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Geriatrics & Gerontology; Neurosciences & Neurology |
| 类目[WOS] | Geriatrics & Gerontology ; Neurosciences |
| 关键词[WOS] | OXIDATIVE STRESS ; ROSMARINIC ACID ; FREE-RADICALS ; CORTICAL-NEURONS ; CELLS ; APOPTOSIS ; ANTIOXIDANTS ; EXTRACT ; NEURODEGENERATION ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297934700016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/538]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, G,Chen, YY,Qin, GW,et al. Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons[J]. NEUROBIOLOGY OF AGING,2012,33(1):176-186. |
| APA | Zhao, G,Chen, YY,Qin, GW,&Guo, LH.(2012).Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons.NEUROBIOLOGY OF AGING,33(1),176-186. |
| MLA | Zhao, G,et al."Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons".NEUROBIOLOGY OF AGING 33.1(2012):176-186. |
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