热门
Long Noncoding RNAs with snoRNA Ends
文献类型：期刊论文
| 作者 | Yin, QF; Yang, L; Zhang, Y; Xiang, JF; Wu, YW; Carmichael, GG; Chen, LL |
| 刊名 | MOLECULAR CELL
 |
| 出版日期 | 2012 |
| 卷号 | 48期号:2页码:219-230 |
| 通讯作者 | Carmichael, GG (reprint author), Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Stem Cell Inst, Farmington, CT 06030 USA.,carmichael@nso2.uchc.edu ; linglingchen@sibcb.ac.cn |
| 英文摘要 | We describe the discovery of sno-IncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (IncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of IncRNAs flanked by snoRNA sequences but lacking 5' caps and 3' poly(A) tails. Such RNAs are widely expressed in cells and tissues and can be produced by either box C/D or box H/ACA snoRNAs. Importantly, the genomic region encoding one abundant class of sno-IncRNAs (15q11-q13) is specifically deleted in Prader-Willi Syndrome (PWS). The PWS region sno-IncRNAs do not colocalize with nucleoli or Cajal bodies, but rather accumulate near their sites of synthesis. These sno-IncRNAs associate strongly with Fox family splicing regulators and alter patterns of splicing. These results thus implicate a previously unannotated class of IncRNAs in the molecular pathogenesis of PWS. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | SMALL NUCLEOLAR RNA ; PRADER-WILLI-SYNDROME ; MAMMALIAN-CELLS ; STEM-CELLS ; PROTEIN ; NUCLEAR ; INTRON ; FOX-1 ; IDENTIFICATION ; TRANSCRIPTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310423800008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/539]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yin, QF,Yang, L,Zhang, Y,et al. Long Noncoding RNAs with snoRNA Ends[J]. MOLECULAR CELL,2012,48(2):219-230. |
| APA | Yin, QF.,Yang, L.,Zhang, Y.,Xiang, JF.,Wu, YW.,...&Chen, LL.(2012).Long Noncoding RNAs with snoRNA Ends.MOLECULAR CELL,48(2),219-230. |
| MLA | Yin, QF,et al."Long Noncoding RNAs with snoRNA Ends".MOLECULAR CELL 48.2(2012):219-230. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。