Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons
文献类型：期刊论文
| 作者 | Zhang, X; Bao, L |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2012 |
| 卷号 | 28期号:2页码:121-130 |
| 关键词 | peripheral nervous system opioid receptor nociceptive pathways |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn |
| 英文摘要 | mu-opioid receptor (MOR) agonists such as morphine are powerful analgesics used for pain therapy. However, the use of these drugs is limited by their side-effects, which include antinociceptive tolerance and dependence. Earlier studies reported that MOR analgesic tolerance is reduced by blockade of delta-opioid receptors (DORs) that interact with MORs. Recent studies show that the MOR/DOR interaction in nociceptive afferent neurons in the dorsal root ganglion may contribute to morphine analgesic tolerance. Further analysis of the mechanisms for regulating the trafficking of receptors, ion channels and signaling molecules in nociceptive afferent neurons would help to understand the nociceptive mechanisms and improve pain therapy. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | DORSAL-ROOT GANGLIA ; PROTEIN-COUPLED RECEPTORS ; DENSE-CORE VESICLES ; RAT SPINAL-CORD ; MORPHINE-TOLERANCE ; MESSENGER-RNAS ; KNOCKOUT MICE ; AUTORADIOGRAPHIC LOCALIZATION ; PHYSICAL-DEPENDENCE ; PERIPHERAL AXOTOMY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304463800005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/543]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, X,Bao, L. Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons[J]. NEUROSCIENCE BULLETIN,2012,28(2):121-130. |
| APA | Zhang, X,&Bao, L.(2012).Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons.NEUROSCIENCE BULLETIN,28(2),121-130. |
| MLA | Zhang, X,et al."Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons".NEUROSCIENCE BULLETIN 28.2(2012):121-130. |
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