miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells
文献类型：期刊论文
| 作者 | Zhao, HJ; Zhu, L; Jin, YJ; Ji, HB; Yan, XM; Zhu, XL |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2012 |
| 卷号 | 44期号:2页码:177-182 |
| 关键词 | small-cell lung cancer miR-375 ASCL1 |
| 通讯作者 | Yan, XM (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,yanx@sibs.ac.cn ; xlzhu@sibs.ac.cn |
| 英文摘要 | In this study, we identified five miRNAs highly expressed in the small-cell lung cancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1). Moreover, miR-375 was upregulated and correlated with ASCL1 in the cell lines generated from mouse SCLC-like tumors as well. Dual-luciferase assays further showed that ASCL1 activated the expression of miR-375 by binding to the three E-box elements in the miR-375 promoter. These results imply a role of ASCL1 in SCLC via the upregulation of miR-375. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | NEUROENDOCRINE ; MICRORNAS ; DIFFERENTIATION ; CARCINOMA ; SURVIVAL ; LINEAGE ; MARKERS ; LOOP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299744000010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/552]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, HJ,Zhu, L,Jin, YJ,et al. miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(2):177-182. |
| APA | Zhao, HJ,Zhu, L,Jin, YJ,Ji, HB,Yan, XM,&Zhu, XL.(2012).miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(2),177-182. |
| MLA | Zhao, HJ,et al."miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.2(2012):177-182. |
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