中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells

文献类型:期刊论文

作者Zhao, HJ; Zhu, L; Jin, YJ; Ji, HB; Yan, XM; Zhu, XL
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期2012
卷号44期号:2页码:177-182
关键词small-cell lung cancer miR-375 ASCL1
通讯作者Yan, XM (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,yanx@sibs.ac.cn ; xlzhu@sibs.ac.cn
英文摘要In this study, we identified five miRNAs highly expressed in the small-cell lung cancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1). Moreover, miR-375 was upregulated and correlated with ASCL1 in the cell lines generated from mouse SCLC-like tumors as well. Dual-luciferase assays further showed that ASCL1 activated the expression of miR-375 by binding to the three E-box elements in the miR-375 promoter. These results imply a role of ASCL1 in SCLC via the upregulation of miR-375.
学科主题Biochemistry & Molecular Biology; Biophysics
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NEUROENDOCRINE ; MICRORNAS ; DIFFERENTIATION ; CARCINOMA ; SURVIVAL ; LINEAGE ; MARKERS ; LOOP
收录类别SCI
语种英语
WOS记录号WOS:000299744000010
版本出版稿
源URL[http://202.127.25.143/handle/331003/552]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
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Zhao, HJ,Zhu, L,Jin, YJ,et al. miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(2):177-182.
APA Zhao, HJ,Zhu, L,Jin, YJ,Ji, HB,Yan, XM,&Zhu, XL.(2012).miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(2),177-182.
MLA Zhao, HJ,et al."miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.2(2012):177-182.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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