Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells
文献类型：期刊论文
| 作者 | Deng, GP; Xiao, Y; Zhou, ZC; Nagai, Y; Zhang, HT; Li, B; Greene, MI |
| 刊名 | EXPERIMENTAL AND MOLECULAR PATHOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 93期号:3页码:334-338 |
| 通讯作者 | Greene, MI (reprint author), Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, 252 John Morgan Bldg,36th St & Hamilton Walk, Philadelphia, PA 19104 USA.,greene@reo.med.upenn.edu |
| 英文摘要 | Regulatory T (Treg) cells are essential in preventing the host from developing certain autoimmune diseases and limiting excessive immune responses against pathogens. The normal function of most Treg cells requires sustained expression of functional FOXP3, a member of the FOXP family transcription factors. FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain. Mutations in this region are occasionally identified in certain patients with X-linked autoimmunity-allergic dysregulation syndrome (XLAAD) and similar mutations also increase susceptibility of autoimmune diseases in rodent models. Previous analyses of the FOXP3 N-terminal domain revealed a role in nuclear import, interaction with other transcription factors, and as sites of specific post-translational modifications of FOXP3 that contribute to FOXP3 stability. (C) 2012 Elsevier Inc. All rights reserved. |
| 学科主题 | Pathology |
| 类目[WOS] | Pathology |
| 关键词[WOS] | TRANSCRIPTION FACTOR FOXP3 ; ROR-GAMMA-T ; HISTONE ACETYLTRANSFERASE ; PROPROTEIN CONVERTASES ; GENE-EXPRESSION ; IPEX SYNDROME ; KAPPA-B ; ACETYLATION ; ACTIVATION ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312466100010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/556]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Deng, GP,Xiao, Y,Zhou, ZC,et al. Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells[J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY,2012,93(3):334-338. |
| APA | Deng, GP.,Xiao, Y.,Zhou, ZC.,Nagai, Y.,Zhang, HT.,...&Greene, MI.(2012).Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.EXPERIMENTAL AND MOLECULAR PATHOLOGY,93(3),334-338. |
| MLA | Deng, GP,et al."Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells".EXPERIMENTAL AND MOLECULAR PATHOLOGY 93.3(2012):334-338. |
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