p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis
文献类型：期刊论文
| 作者 | Schultze, SM; Mairhofer, A; Li, D; Cen, J; Beug, H; Wagner, EF; Hui, LJ |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:3页码:539-550 |
| 关键词 | p38 alpha enucleation stress erythropoiesis Rb |
| 通讯作者 | Hui, LJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Cell Biol, Yueyang Rd 320, Shanghai 200031, Peoples R China.,ljhui@sibs.ac.cn |
| 英文摘要 | Enucleation of erythroblasts during terminal differentiation is unique to mammals. Although erythroid enucleation has been extensively studied, only a few genes, including retinoblastoma protein (Rb), have been identified to regulate nuclear extrusion. It remains largely undefined by which signaling molecules, the extrinsic stimuli, such as erythropoietin (Epo), are transduced to induce enucleation. Here, we show that p38 alpha, a mitogen-activated protein kinase (MAPK), is required for erythroid enucleation. In an ex vivo differentiation system that contains high Epo levels and mimics stress erythropoiesis, p38 alpha is activated during erythroid differentiation. Loss of p38 alpha completely blocks enucleation of primary erythroblasts. Moreover, p38 alpha regulates erythroblast enucleation in a cell-autonomous manner in vivo during fetal and anemic stress erythropoiesis. Markedly, loss of p38 alpha leads to downregulation of p21, and decreased activation of the p21 target Rb, both of which are important regulators of erythroblast enucleation. This study demonstrates that p38 alpha is a key signaling molecule for erythroblast enucleation during stress erythropoiesis. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ACTIVATED PROTEIN-KINASE ; EMBRYONIC STEM-CELLS ; MAP KINASE ; P38 ; PROLIFERATION ; MATURATION ; JNK ; REQUIREMENT ; EXPRESSION ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300942400011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/560]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Schultze, SM,Mairhofer, A,Li, D,et al. p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis[J]. CELL RESEARCH,2012,22(3):539-550. |
| APA | Schultze, SM.,Mairhofer, A.,Li, D.,Cen, J.,Beug, H.,...&Hui, LJ.(2012).p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis.CELL RESEARCH,22(3),539-550. |
| MLA | Schultze, SM,et al."p38 alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis".CELL RESEARCH 22.3(2012):539-550. |
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