Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis
文献类型：期刊论文
| 作者 | Song, W; Wang, JG; Yang, Y; Jing, NH; Zhang, XS; Chen, LN; Wu, JR |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:4页码:197-206 |
| 关键词 | p53 P19 EC cells 5-aza-2-deoxycytidine tumorigenesis network |
| 通讯作者 | Wu, JR (reprint author), Chinese Acad Sci, Key Lab Syst Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,lnchen@sibs.ac.cn ; wujr@sibs.ac.cn |
| 英文摘要 | Many of oncogenes and tumor suppressor genes have been found to exert variable and even opposing roles in different kinds of tumors or at different stages of cancer development. Here we showed that tumorigenic potential of mouse embryonic carcinoma P19 cells cultured in adherent plates (attached-P19-cells) was suppressed by a chemotherapeutic agent, 5-aza-2-deoxycytidine (ZdCyd), whereas the higher pro-tumorigenicity of P19 cells growing in suspension (detached-P19-cells) was generated by the ZdCyd treatment. Surprisingly, p53 activity was highly up-regulated by ZdCyd in both growing conditions. By our developed computational approaches, we revealed that there was a significant enrichment of apoptotic pathways in the ZdCyd-induced p53-dominant gene-regulatory network in attached P19 cells, whereas the pro-survival genes were significantly enriched in the ZdCyd-induced p53 network in detached P19 cells. The proteinprotein interaction network of the ZdCyd-treated detached P19 cells was significantly different from that of ZdCyd-treated attached P19 cells. On the other hand, inhibition of p53 expression by siRNA suppressed the ZdCyd-induced tumorigenesis of detached P19 cells, suggesting that the ZdCyd-activated p53 plays oncogenic function in detached P19 cells. Taken together, these results indicate a context-dependent role for the ZdCyd-activated p53-dominant network in tumorigenesis. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ACUTE PROMYELOCYTIC LEUKEMIA ; EMBRYONIC STEM-CELLS ; DNA-DAMAGE ; TERATOCARCINOMA CELLS ; CARCINOMA-CELLS ; P53 PATHWAY ; CANCER ; GENE ; DIFFERENTIATION ; BIOLOGY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307173900003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/574]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Song, W,Wang, JG,Yang, Y,et al. Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2012,4(4):197-206. |
| APA | Song, W.,Wang, JG.,Yang, Y.,Jing, NH.,Zhang, XS.,...&Wu, JR.(2012).Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis.JOURNAL OF MOLECULAR CELL BIOLOGY,4(4),197-206. |
| MLA | Song, W,et al."Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis".JOURNAL OF MOLECULAR CELL BIOLOGY 4.4(2012):197-206. |
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