Integrin signalling and function in immune cells
文献类型：期刊论文
| 作者 | Zhang, YB; Wang, HY |
| 刊名 | IMMUNOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 135期号:4页码:268-275 |
| 关键词 | adaptor proteins cytoskeleton inside-out signalling integrin activation outside-in signalling |
| 通讯作者 | Wang, HY (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,hongyanwang@sibs.ac.cn |
| 英文摘要 | Integrins not only mediate cellcell and cellextracellular matrix adhesion, but also affect the multitude of signal transduction cascades in control of cell survival, proliferation, differentiation and organ development. Mutations in integrins or the major effectors of integrin signalling pathways cause defective organ development, immunodeficiency, cancer or autoimmune disease. Understanding of the signalling events that drive integrin activation and signalling is therefore crucial to uncover the molecular mechanisms of these diseases. This review discusses the key signalling complexes regulating integrin activation and function in both inside-out and outside-in pathways in T lymphocytes, including kinases, SLP-76, VAV1, ADAP, SKAP-55, RapL, RIAM, Rap1, Talin and Kindlin. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | PROMOTING ADAPTER PROTEIN ; T-CELL ; LEUKOCYTE ADHESION ; TYROSINE KINASE ; IMMUNOLOGICAL SYNAPSE ; THYMOCYTE DEVELOPMENT ; GRANULE POLARIZATION ; ALPHA(4) INTEGRINS ; ENDOTHELIAL-CELLS ; DENDRITIC CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300982500003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/584]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, YB,Wang, HY. Integrin signalling and function in immune cells[J]. IMMUNOLOGY,2012,135(4):268-275. |
| APA | Zhang, YB,&Wang, HY.(2012).Integrin signalling and function in immune cells.IMMUNOLOGY,135(4),268-275. |
| MLA | Zhang, YB,et al."Integrin signalling and function in immune cells".IMMUNOLOGY 135.4(2012):268-275. |
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