Structural Aspects of Ubiquitin Binding Specificities
文献类型：期刊论文
| 作者 | Fu, QS; Song, AX; Hu, HY |
| 刊名 | CURRENT PROTEIN & PEPTIDE SCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 13期号:5页码:482-489 |
| 关键词 | Ubiquitin Ubiquitin-binding domain Ubiquitin-like domain Binding specificity Structural basis |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | Ubiquitin (Ub) is widely distributed in eukaryotic cells as its name means. There are many kinds of Ub-like proteins (for example, SUMO, NEDD8 and ISG15) and Ub-like domains (UbLs) included in multi-domain proteins. To date, a large number of Ub-binding domains (UBDs), such as UBA, CUE, UIM, ZnF, and Pru, are coming up to us with different affinities to Ub and its homologues. The binding specificities provide the basis for controlling various cellular events as well as for delivering ubiquitinated proteins to proteasome for degradation. Structural details of these UBDs and their complexes with Ub might as well show us the delicate mechanism of Ub recognition and regulation. This review summarizes recent progresses on deciphering the structure-based Ub-binding specificities, which are the importantly fundamental elements in orchestrating the ubiquitination and deubiquitination processes in eukaryotic cells. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | 63-LINKED POLYUBIQUITIN CHAINS ; INTERACTING MOTIF ; DEUBIQUITINATING ENZYMES ; UBA DOMAINS ; ISOPEPTIDASE-T ; RECOGNITION ; PROTEINS ; PROTEASOME ; DEGRADATION ; SUBUNIT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309978300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/593]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fu, QS,Song, AX,Hu, HY. Structural Aspects of Ubiquitin Binding Specificities[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2012,13(5):482-489. |
| APA | Fu, QS,Song, AX,&Hu, HY.(2012).Structural Aspects of Ubiquitin Binding Specificities.CURRENT PROTEIN & PEPTIDE SCIENCE,13(5),482-489. |
| MLA | Fu, QS,et al."Structural Aspects of Ubiquitin Binding Specificities".CURRENT PROTEIN & PEPTIDE SCIENCE 13.5(2012):482-489. |
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