mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge
文献类型：期刊论文
| 作者 | Fei, Z; Hu, S; Xiao, L; Zhou, J; Diao, H; Yu, H; Fang, S; Wang, Y; Wan, Y; Wang, W |
| 刊名 | GENES AND IMMUNITY
 |
| 出版日期 | 2012 |
| 卷号 | 13期号:6页码:445-451 |
| 关键词 | antimicrobial peptide defensin mBin1b transgenic epididymis fertility |
| 通讯作者 | Zhang, Y (reprint author), SIBS, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai Key Lab Mol Androl, CAS 320,Yue Yang Rd, Shanghai 200031, Peoples R China.,ylzhang@sibs.ac.cn ; jfei@tongji.edu.cn |
| 英文摘要 | The mBin1b is a beta-defensin gene identified in the mouse epididymis. In the current report, its expression pattern and antibacterial activities were characterized, and a transgenic (TG) mouse model was developed in which mBin1b was exclusively overexpressed by up to 50-fold over normal levels in the caput epididymis. The experimental animals are healthy with normal reproductive activity, but are more resistant to epididymal infection from Escherichia coli than normal animals. The expression of IL1 alpha and IL1 beta in the epididymis was decreased in the TG mice, which suggests that mBin1b has a role in the regulation of inflammatory response in the epididymis. |
| 学科主题 | Genetics & Heredity; Immunology |
| 类目[WOS] | Genetics & Heredity ; Immunology |
| 关键词[WOS] | BETA-DEFENSIN ; EXPRESSION ; IDENTIFICATION ; TRACT ; GENE ; PROMOTER ; FAMILY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308455000001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/611]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fei, Z,Hu, S,Xiao, L,et al. mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge[J]. GENES AND IMMUNITY,2012,13(6):445-451. |
| APA | Fei, Z.,Hu, S.,Xiao, L.,Zhou, J.,Diao, H.,...&Fei, J.(2012).mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge.GENES AND IMMUNITY,13(6),445-451. |
| MLA | Fei, Z,et al."mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge".GENES AND IMMUNITY 13.6(2012):445-451. |
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