Synergistic antitumor effect of TRAIL and IL-24 with complete eradication of hepatoma in the CTGVT-DG strategy
文献类型：期刊论文
| 作者 | Cai, Y; Liu, XR; Huang, WD; Zhang, KJ; Liu, XY |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2012 |
| 卷号 | 44期号:6页码:535-543 |
| 关键词 | TRAIL Mda-7 IL-24 cancer-targeting dual gene-viro-therapy (CTGVT-DG) cancer therapy apoptosis |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | The ZD55-tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and ZD55-interleukin (IL)-24 were constructed by inserting TRAIL or IL-24 gene separately into the oncolytic adenovirus named ZD55 (with adenovirus E1B-55kD deletion). The resulting ZD55-TRAIL and ZD55-IL-24 were used in combination to treat xenograft tumors in nude mice model. The results showed that it can not only completely eliminate BEL7404 hepatoma xenograft but also have excellent antitumor effect against gaster, lung, prostate, and breast carcinomas. It was also found that ZD55-TRAIL could not only suppress the tumor growth promoting effect by ZD55-IL-24 at lower dosage, but also substantially reduce the cancer cell viability in their combined use. This is because ZD55-IL-24 and ZD55-TRAIL could mutually enhance each others antitumor effect greatly. All these findings conspicuously showed the synergistic antitumor effect of TRAIL and IL-24, which is also the reason for the antitumor effect by the combined use of TRAIL and IL-24 in vitro and also in vivo. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | APOPTOSIS-INDUCING LIGAND ; DIFFERENTIATION-ASSOCIATED GENE-7 ; HUMAN BREAST-CANCER ; ONCOLYTIC ADENOVIRUS ; COLORECTAL-CANCER ; PANCREATIC-CANCER ; NUDE-MICE ; TUMOR ; CELLS ; MDA-7/IL-24 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304830700009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/614]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cai, Y,Liu, XR,Huang, WD,et al. Synergistic antitumor effect of TRAIL and IL-24 with complete eradication of hepatoma in the CTGVT-DG strategy[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(6):535-543. |
| APA | Cai, Y,Liu, XR,Huang, WD,Zhang, KJ,&Liu, XY.(2012).Synergistic antitumor effect of TRAIL and IL-24 with complete eradication of hepatoma in the CTGVT-DG strategy.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(6),535-543. |
| MLA | Cai, Y,et al."Synergistic antitumor effect of TRAIL and IL-24 with complete eradication of hepatoma in the CTGVT-DG strategy".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.6(2012):535-543. |
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