3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-Leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects
文献类型：期刊论文
| 作者 | Zhang, YH; Xue, MQ; Bai, YC; Yuan, HH; Zhao, HL; Lan, MB |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2012 |
| 卷号 | 83期号:7页码:1281-1285 |
| 关键词 | 3 Derivatives Artemisia argyi Leucyl-tRNA synthetase Anti-giardial 5-Dicaffeoylquinic acid |
| 通讯作者 | Yuan, HH (reprint author), E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China.,yuanhuihui@ecust.edu.cn ; minbolan@ecust.edu.cn |
| 英文摘要 | An aqueous ethanol extract of Artemisia argyi inhibited the aminoacylation activity of LeuRS from Giardia lamblia (GlLeuRS). The bioassay-guided fractionation of the extract led to the isolation of 3,5-dicaffeoylquinic acid (1), with an IC50 of 5.82 mu g/mL. The ester derivatives of 1 were also found to possess strong anti-GlLeuRS effects, with IC50 values of 1.79, 5.51 and 2.56 mu g/mL respectively. Anti-giardial assay showed that the derivatives, especially 3,5-dicaffeoylquinic acid propyl ester (4) (IC50 =4.62 mu g/mL), were effective at killing G. lamblia. (C) 2012 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 关键词[WOS] | IN-VITRO ; INHIBITION ; L. ; CONSTITUENTS ; INTEGRASE ; RESISTANT ; DOMAIN ; AN2690 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309249000018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/616]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, YH,Xue, MQ,Bai, YC,et al. 3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-Leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects[J]. FITOTERAPIA,2012,83(7):1281-1285. |
| APA | Zhang, YH,Xue, MQ,Bai, YC,Yuan, HH,Zhao, HL,&Lan, MB.(2012).3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-Leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects.FITOTERAPIA,83(7),1281-1285. |
| MLA | Zhang, YH,et al."3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-Leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects".FITOTERAPIA 83.7(2012):1281-1285. |
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