Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration
文献类型：期刊论文
| 作者 | Wu, QF; Yang, L; Li, S; Wang, Q; Yuan, XB; Gao, X; Bao, L; Zhang, X |
| 刊名 | CELL
 |
| 出版日期 | 2012 |
| 卷号 | 149期号:7页码:1549-1564 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn |
| 英文摘要 | Secretory fibroblast growth factors (FGFs) and their receptors are known for their regulatory function in the early stages of neural development. FGF13, a nonsecretory protein of the FGF family, is expressed in cerebral cortical neurons during development and is a candidate gene for syndromal and nonspecific forms of X-chromosome-linked mental retardation (XLMR). However, its function during development remains unclear. We show that FGF13 acts intracellularly as a microtubule-stabilizing protein required for axon and leading process development and neuronal migration in the cerebral cortex. FGF13 is enriched in axonal growth cones and interacts directly with microtubules. Furthermore, FGF13 polymerizes tubulins and stabilizes microtubules. The loss of FGF13 impairs neuronal polarization and increases the branching of axons and leading processes. Genetic deletion of FGF13 in mice results in neuronal migration defects in both the neocortex and the hippocampus. FGF13-deficient mice also exhibit weakened learning and memory, which is correlated to XLMR patients' intellectual disability. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | FACTOR HOMOLOGOUS FACTORS ; MULTIPOLAR STAGE ; NERVOUS-SYSTEM ; DOUBLECORTIN ; MICE ; OUTGROWTH ; MEMORY ; MAP1B ; NUCLEOKINESIS ; TRANSLOCATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000305753800020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/625]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, QF,Yang, L,Li, S,et al. Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration[J]. CELL,2012,149(7):1549-1564. |
| APA | Wu, QF.,Yang, L.,Li, S.,Wang, Q.,Yuan, XB.,...&Zhang, X.(2012).Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration.CELL,149(7),1549-1564. |
| MLA | Wu, QF,et al."Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration".CELL 149.7(2012):1549-1564. |
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