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A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
文献类型：期刊论文
| 作者 | Jiang, S; Zhang, LF; Zhang, HW; Hu, S; Lu, MH; Liang, S; Li, B; Li, Y; Li, DS; Wang, ED |
| 刊名 | EMBO JOURNAL
 |
| 出版日期 | 2012 |
| 卷号 | 31期号:8页码:1985-1998 |
| 关键词 | aerobic glycolysis hexokinase 2 inflammation microRNA-155 microRNA-143 the Warburg effect |
| 通讯作者 | Liu, MF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,mfliu@sibs.ac.cn |
| 英文摘要 | Cancer cells preferentially metabolize glucose through aerobic glycolysis. This phenomenon, known as the Warburg effect, is an anomalous characteristic of glucose metabolism in cancer cells. Chronic inflammation is a key promoting factor of tumourigenesis. It remains, however, largely unexplored whether and how pro-tumourigenic inflammation regulates glucose metabolism in cancer cells. Here, we show that pro-inflammatory cytokines promote glycolysis in breast cancer cells, and that the inflammation- induced miR-155 functions as an important mediator in this process. We further show that miR-155 acts to upregulate hexokinase 2 (hk2), through two distinct mechanisms. First, miR-155 promotes hk2 transcription by activation of signal transducer and activator of transcription 3 (STAT3), a transcriptional activator for hk2. Second, via targeting C/EBP beta (a transcriptional activator for mir143), miR-155 represses mir-143, a negative regulator of hk2, thus resulting in upregulation of hk2 expression at the post-transcriptional level. The miR-155-mediated hk2 upregulation also appears to operate in other types of cancer cells examined. We suggest that the miR-155/miR-143/HK2 axis may represent a common mechanism linking inflammation to the altered metabolism in cancer cells. The EMBO Journal (2012) 31, 1985-1998. doi:10.1038/emboj.2012.45; Published online 21 February 2012 Subject Categories: signal transduction; molecular biology of disease |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | POSITRON-EMISSION-TOMOGRAPHY ; NF-KAPPA-B ; TUMOR-SUPPRESSOR GENE ; CONSTITUTIVE ACTIVATION ; INFLAMMATORY RESPONSE ; TRANSCRIPTION FACTORS ; GLUCOSE CATABOLISM ; II HEXOKINASE ; TARGET GENE ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303108600013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/632]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jiang, S,Zhang, LF,Zhang, HW,et al. A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells[J]. EMBO JOURNAL,2012,31(8):1985-1998. |
| APA | Jiang, S.,Zhang, LF.,Zhang, HW.,Hu, S.,Lu, MH.,...&Liu, MF.(2012).A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.EMBO JOURNAL,31(8),1985-1998. |
| MLA | Jiang, S,et al."A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells".EMBO JOURNAL 31.8(2012):1985-1998. |
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