Genome-scale study of transcription factor expression in the branching mouse lung
文献类型：期刊论文
| 作者 | Herriges, JC; Yi, L; Hines, EA; Harvey, JF; Xu, GL; Gray, PA; Ma, QF; Sun, X |
| 刊名 | DEVELOPMENTAL DYNAMICS
 |
| 出版日期 | 2012 |
| 卷号 | 241期号:9页码:1432-1453 |
| 关键词 | lung mouse transcription factors expression patterns branching |
| 通讯作者 | Sun, X (reprint author), Univ Wisconsin, Genet Lab, Madison, WI 53706 USA.,xsun@wisc.edu |
| 英文摘要 | Background: Mammalian lung development consists of a series of precisely choreographed events that drive the progression from simple lung buds to the elaborately branched organ that fulfills the vital function of gas exchange. Strict transcriptional control is essential for lung development. Among the large number of transcription factors encoded in the mouse genome, only a small portion of them are known to be expressed and function in the developing lung. Thus a systematic investigation of transcription factors expressed in the lung is warranted. Results: To enrich for genes that may be responsible for regional growth and patterning, we performed a screen using RNA in situ hybridization to identify genes that show restricted expression patterns in the embryonic lung. We focused on the pseudoglandular stage during which the lung underergoes branching morphogenesis, a cardinal event of lung development. Using a genome-scale probe set that represents over 90% of the transcription factors encoded in the mouse genome, we identified 62 transcription factor genes with localized expression in the epithelium, mesenchyme, or both. Many of these genes have not been previously implicated in lung development. Conclusions: Our findings provide new starting points for the elucidation of the transcriptional circuitry that controls lung development. Developmental Dynamics 241:1432-1453, 2012. (c) 2012 Wiley Periodicals, Inc. |
| 学科主题 | Anatomy & Morphology; Developmental Biology |
| 类目[WOS] | Anatomy & Morphology ; Developmental Biology |
| 关键词[WOS] | ENDOPLASMIC-RETICULUM STRESS ; EPITHELIAL-MESENCHYMAL INTERACTIONS ; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; EXTRACELLULAR-MATRIX PRODUCTION ; CHROMATIN REMODELING COMPLEXES ; MORPHOGENETIC PROTEIN-4 BMP-4 ; OBSTRUCTIVE PULMONARY-DISEASE ; POLYCYSTIC KIDNEY-DISEASE ; IROQUOIS HOMEOBOX GENES ; VASCULAR SMOOTH-MUSCLE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307882200006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/641]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Herriges, JC,Yi, L,Hines, EA,et al. Genome-scale study of transcription factor expression in the branching mouse lung[J]. DEVELOPMENTAL DYNAMICS,2012,241(9):1432-1453. |
| APA | Herriges, JC.,Yi, L.,Hines, EA.,Harvey, JF.,Xu, GL.,...&Sun, X.(2012).Genome-scale study of transcription factor expression in the branching mouse lung.DEVELOPMENTAL DYNAMICS,241(9),1432-1453. |
| MLA | Herriges, JC,et al."Genome-scale study of transcription factor expression in the branching mouse lung".DEVELOPMENTAL DYNAMICS 241.9(2012):1432-1453. |
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