A statin-regulated microRNA represses human c-Myc expression and function
文献类型：期刊论文
| 作者 | Takwi, AAL; Li, Y; Buscaglia, LEB; Zhang, JW; Choudhury, S; Park, AK; Liu, MF; Young, KH; Park, WY; Martin, RCG |
| 刊名 | EMBO MOLECULAR MEDICINE
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:9页码:896-909 |
| 关键词 | c-Myc lovastatin medulloblastoma microRNA miR-33b |
| 通讯作者 | Li, Y (reprint author), Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA.,yong.li@louisville.edu ; yong.li@louisville.edu |
| 英文摘要 | c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In this work, we identified miR-33b as a primate-specific negative regulator of c-Myc. The human miR-33b gene is located at 17p11.2, a genomic locus frequently lost in medulloblastomas, of which a subset displays c-Myc overproduction. Through a small-scale screening with drugs approved by the US Food and Drug Administration (FDA), we found that lovastatin upregulated miR-33b expression, reduced cell proliferation and impaired c-Myc expression and function in miR-33b-positive medulloblastoma cells. In addition, a low dose of lovastatin treatment at a level comparable to approved human oral use reduced tumour growth in mice orthotopically xenografted with cells carrying miR-33b, but not with cells lacking miR-33b. This work presents a highly promising therapeutic option, using drug repurposing and a miRNA as a biomarker, against cancers that overexpress c-Myc. |
| 学科主题 | Research & Experimental Medicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 关键词[WOS] | LOVASTATIN-INDUCED APOPTOSIS ; MEDULLOBLASTOMA CELL-LINES ; SMITH-MAGENIS-SYNDROME ; PLURIPOTENT STEM-CELLS ; PEDIATRIC MEDULLOBLASTOMA ; CHOLESTEROL HOMEOSTASIS ; COLORECTAL-CANCER ; IN-VIVO ; N-MYC ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308302900008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/642]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Takwi, AAL,Li, Y,Buscaglia, LEB,et al. A statin-regulated microRNA represses human c-Myc expression and function[J]. EMBO MOLECULAR MEDICINE,2012,4(9):896-909. |
| APA | Takwi, AAL.,Li, Y.,Buscaglia, LEB.,Zhang, JW.,Choudhury, S.,...&Li, Y.(2012).A statin-regulated microRNA represses human c-Myc expression and function.EMBO MOLECULAR MEDICINE,4(9),896-909. |
| MLA | Takwi, AAL,et al."A statin-regulated microRNA represses human c-Myc expression and function".EMBO MOLECULAR MEDICINE 4.9(2012):896-909. |
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