Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression
文献类型：期刊论文
| 作者 | Zhang, KJ; Zhang, J; Wu, YM; Qian, J; Liu, XJ; Yan, LC; Zhou, XM; Xiao, RJ; Wang, YG; Cao, X |
| 刊名 | CANCER GENE THERAPY
 |
| 出版日期 | 2012 |
| 卷号 | 19期号:9页码:619-629 |
| 关键词 | Cancer Targeting Gene-Viro-Therapy complete eradication E1B deletion hepatoma specificity IL-24 |
| 通讯作者 | Liu, XY (reprint author), Zhejiang Sci Tech Univ, XinYuan Inst Med & Biotechnol, Coll Life Sci, Hangzhou 310018, Zhejiang, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | Interleukin (IL)-24, a promising therapeutic gene, has been widely used for Cancer Targeting Gene-Viro-Therapy (CTGVT). In this study, IL-24 was inserted into an oncolytic adenovirus in which the E1A gene is driven by an enhanced, short alpha-fetoprotein (AFP) promoter and the E1B gene is completely deleted to form Ad.enAFP-E1A-Delta E1B-IL-24. This construct has a potent antitumor effect on liver cancer cell lines in vitro, but little or no effect on normal cell lines, such as L-02 and QSG-7701. In vivo, the complete elimination of Huh-7 liver cancer in nude mice with Ad.enAFP-E1A-Delta E1B-IL-24 intratumor injection was observed. The design of Ad.enAFP-E1A-Delta E1B-IL-24 and its potent antitumor effect on liver cancer have not been published previously. The mechanism of the potent antitumor effect of Ad.enAFP-E1A-Delta E1B-IL-24 is due to the upregulation of GADD34 and intrinsic and extrinsic apoptotic signaling. |
| 学科主题 | Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity; Research & Experimental Medicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental |
| 关键词[WOS] | LUNG-CANCER CELLS ; DIFFERENTIATION-ASSOCIATED GENE-7 ; NECROSIS-FACTOR-ALPHA ; HEPATOCELLULAR-CARCINOMA ; MELANOMA DIFFERENTIATION ; IN-VIVO ; 19-KILODALTON PROTEIN ; INTERLEUKIN-24 GENE ; ANTITUMOR-ACTIVITY ; COLORECTAL-CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307706600004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/643]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, KJ,Zhang, J,Wu, YM,et al. Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression[J]. CANCER GENE THERAPY,2012,19(9):619-629. |
| APA | Zhang, KJ.,Zhang, J.,Wu, YM.,Qian, J.,Liu, XJ.,...&Liu, XY.(2012).Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression.CANCER GENE THERAPY,19(9),619-629. |
| MLA | Zhang, KJ,et al."Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression".CANCER GENE THERAPY 19.9(2012):619-629. |
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