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Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-Activated Receptor-gamma Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis
文献类型：期刊论文
| 作者 | Chang, L; Villacorta, L; Li, RX; Hamblin, M; Xu, W; Dou, CY; Zhang, JF; Wu, JR; Zeng, R; Chen, YE |
| 刊名 | CIRCULATION
 |
| 出版日期 | 2012 |
| 卷号 | 126期号:9页码:1067-U174 |
| 关键词 | cold temperature thermoregulation PPAR gamma adipose tissue perivascular adipose tissue brown |
| 通讯作者 | Chen, YE (reprint author), Univ Michigan, Med Ctr, Dept Internal Med, Cardiovasc Ctr, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.,echenum@umich.edu |
| 英文摘要 | Background-Perivascular adipose tissue (PVAT) surrounds most vessels and shares common features with brown adipose tissue (BAT). Although adaptive thermogenesis in BAT increases energy expenditure and is beneficial for metabolic diseases, little is known about the role of PVAT in vascular diseases such as atherosclerosis. We hypothesize that the thermogenic function of PVAT regulates intravascular temperature and reduces atherosclerosis. Methods and Results-PVAT shares similar structural and proteomics with BAT. We demonstrated that PVAT has thermogenic properties similar to BAT in response to cold stimuli in vivo. Proteomics analysis of the PVAT from mice housed in a cold environment identified differential expression in proteins highly related to cellular metabolic processes. In a mouse model deficient in peroxisome proliferator-activated receptor- gamma in smooth muscle cells (SMPG KO mice), we uncovered a complete absence of PVAT surrounding the vasculature, likely caused by peroxisome proliferator-activated receptor- gamma deletion in the perivascular adipocyte precursor cells as well. Lack of PVAT, which results in loss of its thermogenic activity, impaired vascular homeostasis, which caused temperature loss and endothelial dysfunction. We further showed that cold exposure inhibits atherosclerosis and improves endothelial function in mice with intact PVAT but not in SMPG KO mice as a result of impaired lipid clearance. Proinflammatory cytokine expression in PVAT is not altered on exposure to cold. Finally, prostacyclin released from PVAT contributes to the vascular protection against endothelial dysfunction. Conclusions-PVAT is a vasoactive organ with functional characteristics similar to BAT and is essential for intravascular thermoregulation of cold acclimation. This thermogenic capacity of PVAT plays an important protective role in the pathogenesis of atherosclerosis. (Circulation. 2012;126:1067-1078.) |
| 学科主题 | Cardiovascular System & Cardiology |
| 类目[WOS] | Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease |
| 关键词[WOS] | CORONARY-ARTERIES ; MEMBRANE-PROTEINS ; VASCULAR FUNCTION ; ADULT HUMANS ; INFLAMMATION ; COLD ; FAT ; THERMOGENESIS ; ACETYLCHOLINE ; INSULIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308355100017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/644]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chang, L,Villacorta, L,Li, RX,et al. Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-Activated Receptor-gamma Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis[J]. CIRCULATION,2012,126(9):1067-U174. |
| APA | Chang, L.,Villacorta, L.,Li, RX.,Hamblin, M.,Xu, W.,...&Chen, YE.(2012).Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-Activated Receptor-gamma Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis.CIRCULATION,126(9),1067-U174. |
| MLA | Chang, L,et al."Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-Activated Receptor-gamma Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis".CIRCULATION 126.9(2012):1067-U174. |
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