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Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
文献类型：期刊论文
| 作者 | Min, LH; Ji, Y; Bakiri, L; Qiu, ZX; Cen, J; Chen, XT; Chen, LL; Scheuch, H; Zheng, H; Qin, LX |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 14期号:11页码:1203-1203 |
| 通讯作者 | Hui, LJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Yueyang Rd 320, Shanghai 200031, Peoples R China.,ljhui@sibs.ac.cn ; ewagner@cnio.es |
| 英文摘要 | Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies. The mechanisms acting during cancer initiation remain elusive, largely owing to a lack of suitable animal models and limited availability of human precancerous lesions. Here we show using genetic mouse models specific for liver cancer initiation, that survival of initiated cancer cells is controlled by c-Jun, independently of p53, through suppressing c-Fos-mediated apoptosis. Mechanistically, c-Fos induces SIRT6 transcription, which represses survivin by reducing histone H3K9 acetylation and NF-kappa B activation. Importantly, increasing the level of SIRT6 or targeting the anti-apoptotic activity of survivin at the initiation stage markedly impairs cancer development. Moreover, in human dysplastic liver nodules, but not in malignant tumours, a special expression pattern with increased c-Jun-survivin and attenuated c-Fos-SIRT6 levels was identified. These results reveal a regulatory network connecting stress response and histone modification in liver tumour initiation, which could be targeted to prevent liver tumorigenesis. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | P53-MEDIATED TUMOR SUPPRESSION ; HEPATOCELLULAR-CARCINOMA ; GENE-EXPRESSION ; TUMORIGENESIS ; PROLIFERATION ; ACTIVATION ; PATHWAY ; SIRT6 ; FOS ; HEPATOCARCINOGENESIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310778100013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/658]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Min, LH,Ji, Y,Bakiri, L,et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin[J]. NATURE CELL BIOLOGY,2012,14(11):1203-1203. |
| APA | Min, LH.,Ji, Y.,Bakiri, L.,Qiu, ZX.,Cen, J.,...&Wagner, EF.(2012).Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.NATURE CELL BIOLOGY,14(11),1203-1203. |
| MLA | Min, LH,et al."Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin".NATURE CELL BIOLOGY 14.11(2012):1203-1203. |
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