Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies
文献类型：期刊论文
| 作者 | Yang, AP; Ma, JX; Wu, M; Qin, WM; Zhao, BT; Shi, Y; Jin, YX; Xie, YH |
| 刊名 | LEUKEMIA & LYMPHOMA
 |
| 出版日期 | 2012 |
| 卷号 | 53期号:12页码:2465-2473 |
| 关键词 | Lymphoblastic malignancies glucocorticoid resistance MIR182 FOXO3A BIM |
| 通讯作者 | Xie, YH (reprint author), Fudan Univ, Dept Hematol, Huadong Hosp, 221 W Yanan Rd, Shanghai 200433, Peoples R China.,yxjin@sibs.ac.cn ; xyh@medmail.com.cn |
| 英文摘要 | Glucocorticoid (GC) resistance in lymphoblastic malignancies is related to treatment failure and is a marker of poor prognosis. Previous studies have suggested that microRNA-182 (miR-182) functions as an oncogene and plays a role in tumorigenesis, through regulation of FOXO3A. FOXO3A has been implicated in tumor suppression and GC-induced apoptosis, suggesting that FOXO3A has potential as a therapeutic target. Herein we investigated the role of miR-182 in GC sensitivity in lymphoblastic malignancies. Expression of miR-182 was consistently higher in human and mouse GC-resistant cell lines than in GC-sensitive cell lines. Furthermore, increased expression of miR-182 reduced total FOXO3A expression but had no significant effect on phospho-FOXO3A. Additionally Bim, as a downstream target of FOXO3A, was reduced by overexpression of miR-182, and increased by down-regulation of miR-182. These results demonstrate that miR-182 is involved in glucocorticoid resistance, via targeting of FOXO3A, and that restoration of miR-182 is a potentially promising therapeutic strategy in lymphoblastic malignancies. |
| 学科主题 | Oncology; Hematology |
| 类目[WOS] | Oncology ; Hematology |
| 关键词[WOS] | FORKHEAD TRANSCRIPTION FACTOR ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; INDUCED APOPTOSIS ; BREAST-CANCER ; PROMOTES TUMORIGENESIS ; DOWN-REGULATION ; FACTOR FKHR-L1 ; CELL-SURVIVAL ; SMALL RNAS ; FOXO3A |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310709000024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/668]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, AP,Ma, JX,Wu, M,et al. Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies[J]. LEUKEMIA & LYMPHOMA,2012,53(12):2465-2473. |
| APA | Yang, AP.,Ma, JX.,Wu, M.,Qin, WM.,Zhao, BT.,...&Xie, YH.(2012).Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies.LEUKEMIA & LYMPHOMA,53(12),2465-2473. |
| MLA | Yang, AP,et al."Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies".LEUKEMIA & LYMPHOMA 53.12(2012):2465-2473. |
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