中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies

文献类型:期刊论文

作者Yang, AP; Ma, JX; Wu, M; Qin, WM; Zhao, BT; Shi, Y; Jin, YX; Xie, YH
刊名LEUKEMIA & LYMPHOMA
出版日期2012
卷号53期号:12页码:2465-2473
关键词Lymphoblastic malignancies glucocorticoid resistance MIR182 FOXO3A BIM
通讯作者Xie, YH (reprint author), Fudan Univ, Dept Hematol, Huadong Hosp, 221 W Yanan Rd, Shanghai 200433, Peoples R China.,yxjin@sibs.ac.cn ; xyh@medmail.com.cn
英文摘要Glucocorticoid (GC) resistance in lymphoblastic malignancies is related to treatment failure and is a marker of poor prognosis. Previous studies have suggested that microRNA-182 (miR-182) functions as an oncogene and plays a role in tumorigenesis, through regulation of FOXO3A. FOXO3A has been implicated in tumor suppression and GC-induced apoptosis, suggesting that FOXO3A has potential as a therapeutic target. Herein we investigated the role of miR-182 in GC sensitivity in lymphoblastic malignancies. Expression of miR-182 was consistently higher in human and mouse GC-resistant cell lines than in GC-sensitive cell lines. Furthermore, increased expression of miR-182 reduced total FOXO3A expression but had no significant effect on phospho-FOXO3A. Additionally Bim, as a downstream target of FOXO3A, was reduced by overexpression of miR-182, and increased by down-regulation of miR-182. These results demonstrate that miR-182 is involved in glucocorticoid resistance, via targeting of FOXO3A, and that restoration of miR-182 is a potentially promising therapeutic strategy in lymphoblastic malignancies.
学科主题Oncology; Hematology
类目[WOS]Oncology ; Hematology
关键词[WOS]FORKHEAD TRANSCRIPTION FACTOR ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; INDUCED APOPTOSIS ; BREAST-CANCER ; PROMOTES TUMORIGENESIS ; DOWN-REGULATION ; FACTOR FKHR-L1 ; CELL-SURVIVAL ; SMALL RNAS ; FOXO3A
收录类别SCI
语种英语
WOS记录号WOS:000310709000024
版本出版稿
源URL[http://202.127.25.143/handle/331003/668]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Yang, AP,Ma, JX,Wu, M,et al. Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies[J]. LEUKEMIA & LYMPHOMA,2012,53(12):2465-2473.
APA Yang, AP.,Ma, JX.,Wu, M.,Qin, WM.,Zhao, BT.,...&Xie, YH.(2012).Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies.LEUKEMIA & LYMPHOMA,53(12),2465-2473.
MLA Yang, AP,et al."Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies".LEUKEMIA & LYMPHOMA 53.12(2012):2465-2473.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。