Molecular basis for population variation: From SNPs to SAPs
文献类型：期刊论文
| 作者 | Wu, JR; Zeng, R |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 586期号:18页码:2841-2845 |
| 关键词 | SNP Single amino-acid polymorphism (SAP) RNA editome Protein editing The Central Dogma |
| 通讯作者 | Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.,wujr@sibs.ac.cn ; zr@sibs.ac.cn |
| 英文摘要 | Single nucleotide polymorphisms (SNPs) are one type of genomic DNA variations in a population. Correspondingly, single amino-acid polymorphisms (SAPs) derived from non-synonymous SNPs represent protein variations in a population. Recently, using proteomic approaches, SAPs in the plasma proteomes of an Asian population were systematically identified for the first time. That study showed that heterozygous and homozygous proteins with various SAPs have different associations with particular traits in the population. Recent discoveries of widespread differences between RNA and DNA sequences indicate that RNA editing is also a source of SAPs - one that is independent of genomic SNPs. Furthermore, we argue that there are de novo SAPs that are not encoded by either DNA or RNA sequences. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | SINGLE-NUCLEOTIDE POLYMORPHISMS ; AMINO-ACID POLYMORPHISMS ; TRANSFER-RNA SYNTHETASES ; DNA-SEQUENCE DIFFERENCES ; HUMAN GENE-EXPRESSION ; HUMAN TRANSCRIPTOME ; SHOTGUN PROTEOMICS ; POTENTIALLY RELEVANT ; PROTEIN-SYNTHESIS ; WIDESPREAD RNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307825000007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/679]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, JR,Zeng, R. Molecular basis for population variation: From SNPs to SAPs[J]. FEBS LETTERS,2012,586(18):2841-2845. |
| APA | Wu, JR,&Zeng, R.(2012).Molecular basis for population variation: From SNPs to SAPs.FEBS LETTERS,586(18),2841-2845. |
| MLA | Wu, JR,et al."Molecular basis for population variation: From SNPs to SAPs".FEBS LETTERS 586.18(2012):2841-2845. |
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