Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae
文献类型：期刊论文
| 作者 | Zhou, BO; Wang, SS; Zhang, Y; Fu, XH; Dang, W; Lenzmeier, BA; Zhou, JQ |
| 刊名 | PLOS GENETICS
 |
| 出版日期 | 2011 |
| 卷号 | 7期号:1页码:e1001272-e1001272 |
| 通讯作者 | Zhou, BO (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai, Peoples R China.,jqzhou@sibs.ac.cn |
| 英文摘要 | Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure. In this study, we show that histones are dynamically acetylated on H4K12 at telomeric heterochromatin, and this acetylation regulates several of the dynamic telomere properties. Using a de novo heterochromatin formation assay, we surprisingly found that acetylated H4K12 survived the formation of telomeric heterochromatin. Consistently, the histone acetyltransferase complex NuA4 bound to silenced telomeric regions and acetylated H4K12. H4K12 acetylation prevented the over-accumulation of Sir proteins at telomeric heterochromatin and elimination of this acetylation caused defects in multiple telomere-related processes, including transcription, telomere replication, and recombination. Together, these data shed light on a potential histone acetylation mark within telomeric heterochromatin that contributes to telomere plasticity. |
| 学科主题 | Genetics & Heredity |
| 类目[WOS] | Genetics & Heredity |
| 关键词[WOS] | SILENT CHROMATIN ; YEAST HETEROCHROMATIN ; DNA-REPLICATION ; SIR4 PROTEINS ; VARIANT H2A.Z ; BINDING ; ACETYLTRANSFERASE ; COMPLEX ; H3 ; RECOMBINATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286653500011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/714]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, BO,Wang, SS,Zhang, Y,et al. Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae[J]. PLOS GENETICS,2011,7(1):e1001272-e1001272. |
| APA | Zhou, BO.,Wang, SS.,Zhang, Y.,Fu, XH.,Dang, W.,...&Zhou, JQ.(2011).Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae.PLOS GENETICS,7(1),e1001272-e1001272. |
| MLA | Zhou, BO,et al."Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae".PLOS GENETICS 7.1(2011):e1001272-e1001272. |
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