Emodin inhibits current through SARS-associated coronavirus 3a protein
文献类型：期刊论文
| 作者 | Schwarz, S; Wang, K; Yu, WJ; Sun, B; Schwarz, W |
| 刊名 | ANTIVIRAL RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 90期号:1页码:64-69 |
| 关键词 | 3a protein Corona virus Emodin Voltage clamp Ion channel Virus release |
| 通讯作者 | Schwarz, W (reprint author), Goethe Univ Frankfurt, Inst Biophys, Max von Laue Str 1, D-600438 Frankfurt, Germany.,schwarz@biophys.eu |
| 英文摘要 | The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K(1/2) value of about 20 mu M. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents. (C) 2011 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Virology |
| 类目[WOS] | Pharmacology & Pharmacy ; Virology |
| 关键词[WOS] | ANGIOTENSIN-CONVERTING ENZYME-2 ; FUNCTIONAL RECEPTOR ; SPIKE PROTEIN ; ION CHANNELS ; CELLS ; ANGIOTENSIN-CONVERTING-ENZYME-2 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290288100008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/719]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Schwarz, S,Wang, K,Yu, WJ,et al. Emodin inhibits current through SARS-associated coronavirus 3a protein[J]. ANTIVIRAL RESEARCH,2011,90(1):64-69. |
| APA | Schwarz, S,Wang, K,Yu, WJ,Sun, B,&Schwarz, W.(2011).Emodin inhibits current through SARS-associated coronavirus 3a protein.ANTIVIRAL RESEARCH,90(1),64-69. |
| MLA | Schwarz, S,et al."Emodin inhibits current through SARS-associated coronavirus 3a protein".ANTIVIRAL RESEARCH 90.1(2011):64-69. |
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