Mitogen-activated protein kinases in hepatocellular carcinoma development
文献类型：期刊论文
| 作者 | Min, LH; He, BK; Hui, LJ |
| 刊名 | SEMINARS IN CANCER BIOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:1页码:42297 |
| 关键词 | MAPKs Hepatocellular carcinoma (HCC) Proliferation Apoptosis Inflammation Targeted therapy |
| 通讯作者 | Hui, LJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Yueyang Rd 320, Shanghai 200031, Peoples R China.,ljhui@sibs.ac.cn |
| 英文摘要 | Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs), comprising a family of serine and threonine kinases of ERK, JNK, and p38, are important signaling components which convert external stimuli into a wide range of cellular responses, such as proliferation, survival, differentiation and migration. Due to their essential roles in these cellular functions, deregulated MAPKs are often found to contribute to the development of many cancers, including HCC. Markedly, early studies on the ERK pathway have led to the development of the multikinase inhibitor Sorafenib, the first effective systemic drug for the targeted treatment of human HCC. Recently, the functions and molecular mechanisms of JNK and p38 in HCC development have also been addressed using mouse models. In this review, we discuss the latest findings regarding the ERK, JNK and p38 MAPK signaling pathways in HCC development and their potential roles as therapeutic targets for HCC. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | NF-KAPPA-B ; JUN NH2-TERMINAL KINASE ; P38-ALPHA MAP KINASE ; REGULATES CELL-MIGRATION ; YES-ASSOCIATED PROTEIN ; JNK SIGNALING PATHWAY ; TUMOR-NECROSIS-FACTOR ; VIRUS X-PROTEIN ; GROWTH IN-VITRO ; TERMINAL KINASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288840900003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/722]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Min, LH,He, BK,Hui, LJ. Mitogen-activated protein kinases in hepatocellular carcinoma development[J]. SEMINARS IN CANCER BIOLOGY,2011,21(1):42297. |
| APA | Min, LH,He, BK,&Hui, LJ.(2011).Mitogen-activated protein kinases in hepatocellular carcinoma development.SEMINARS IN CANCER BIOLOGY,21(1),42297. |
| MLA | Min, LH,et al."Mitogen-activated protein kinases in hepatocellular carcinoma development".SEMINARS IN CANCER BIOLOGY 21.1(2011):42297. |
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