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Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation
文献类型：期刊论文
| 作者 | He, SQ; Zhang, ZN; Guan, JS; Liu, HR; Zhao, B; Wang, HB; Li, QA; Yang, H; Luo, J; Li, ZY |
| 刊名 | NEURON
 |
| 出版日期 | 2011 |
| 卷号 | 69期号:1页码:120-131 |
| 通讯作者 | Bao, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,baolan@sibs.ac.cn ; xu.zhang@ion.ac.cn |
| 英文摘要 | delta-opioid receptors (DORs) form heteromers with mu-opioid receptors (MORs) and negatively regulate MOR-mediated spinal analgesia. However, the underlying mechanism remains largely unclear. The present study shows that the activity of MORs can be enhanced by preventing MORs from DOR-mediated codegradation. Treatment with DOR-specific agonists led to endocytosis of both DORs and MORs. These receptors were further processed for ubiquitination and lysosomal degradation, resulting in a reduction of surface MORs. Such effects were attenuated by treatment with an interfering peptide containing the first transmembrane domain of MOR (MOR(Tm1)), which interacted with DORs and disrupted the MOR/DOR interaction. Furthermore, the systemically applied fusion protein consisting of MOR(TM1) and TAT at the C terminus could disrupt the MOR/DOR interaction in the mouse spinal cord, enhance the morphine analgesia, and reduce the antinociceptive tolerance to morphine. Thus, dissociation of MORs from DORs in the cell membrane is a potential strategy to improve opioid analgesic therapies. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | DORSAL-ROOT GANGLIA ; PROTEIN-COUPLED RECEPTORS ; NOXIOUS THERMAL STIMULI ; RAT SPINAL-CORD ; KNOCK-OUT MICE ; DOWN-REGULATION ; PHYSICAL-DEPENDENCE ; MORPHINE ANALGESIA ; SUBSTANCE-P ; TOLERANCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286446300012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/723]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | He, SQ,Zhang, ZN,Guan, JS,et al. Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation[J]. NEURON,2011,69(1):120-131. |
| APA | He, SQ.,Zhang, ZN.,Guan, JS.,Liu, HR.,Zhao, B.,...&Zhang, X.(2011).Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation.NEURON,69(1),120-131. |
| MLA | He, SQ,et al."Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation".NEURON 69.1(2011):120-131. |
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