Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos
文献类型：期刊论文
| 作者 | Li, XA; Zhu, LL; Yang, AC; Lin, JW; Tang, F; Jin, SB; Wei, Z; Li, JS; Jin, Y |
| 刊名 | CELL STEM CELL
 |
| 出版日期 | 2011 |
| 卷号 | 8期号:1页码:46-58 |
| 通讯作者 | Jin, Y (reprint author), Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci,Shanghai Ins, Shanghai 200025, Peoples R China.,yjin@sibs.ac.cn |
| 英文摘要 | Self-renewal and pluripotency are hallmarks of embryonic stem cells (ESCs). However, the signaling pathways that trigger their transition from self-renewal to differentiation remain elusive. Here, we report that calcineurin-NFAT signaling is both necessary and sufficient to switch ESCs from an undifferentiated state to lineage-specific cells and that the inhibition of this pathway can maintain long-term ESC self-renewal independent of leukemia inhibitory factor. Mechanistically, this pathway converges with the Erk1/2 pathway to regulate Src expression and promote the epithelial-mesenchymal transition (EMT), a process required for lineage specification in response to differentiation stimuli. Furthermore, calcineurin-NFAT signaling is activated when the earliest differentiation event occurs in mouse embryos, and its inhibition disrupts extraembryonic lineage development. Collectively, our results demonstrate that the NFAT and Erk1/2 cascades form a signaling switch for early lineage segregation in mouse ESCs and provide significant insights into the regulation of the balance between ESC self-renewal and early lineage specification, |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell & Tissue Engineering ; Cell Biology |
| 关键词[WOS] | EPITHELIAL-MESENCHYMAL TRANSITIONS ; DEPENDENT TRANSCRIPTIONAL PATHWAY ; SELF-RENEWAL ; LYMPHOCYTE-ACTIVATION ; PRIMITIVE ENDODERM ; GENE-EXPRESSION ; KINASE-ACTIVITY ; SRC FAMILY ; C-SRC ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286786200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/724]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, XA,Zhu, LL,Yang, AC,et al. Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos[J]. CELL STEM CELL,2011,8(1):46-58. |
| APA | Li, XA.,Zhu, LL.,Yang, AC.,Lin, JW.,Tang, F.,...&Jin, Y.(2011).Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos.CELL STEM CELL,8(1),46-58. |
| MLA | Li, XA,et al."Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos".CELL STEM CELL 8.1(2011):46-58. |
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