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Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
文献类型：期刊论文
| 作者 | Tang, JJ; Li, JG; Qi, W; Qiu, WW; Li, PS; Li, BL; Song, BL |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2011 |
| 卷号 | 13期号:1页码:44-56 |
| 通讯作者 | Song, BL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,blsong@sibs.ac.cn |
| 英文摘要 | Sterol regulatory element-binding proteins (SREBPs) are major transcription factors activating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride. In this study, we identified a small molecule, betulin, that specifically inhibited the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. Inhibition of SREBP by betulin decreased the biosynthesis of cholesterol and fatty acid. In vivo, betulin ameliorated diet-induced obesity, decreased the lipid contents in serum and tissues, and increased insulin sensitivity. Furthermore, betulin reduced the size and improved the stability of atherosclerotic plaques. Our study demonstrates that inhibition SREBP pathway can be employed as a therapeutic strategy to treat metabolic diseases including type II diabetes and atherosclerosis. Betulin, which is abundant in birch bark, could be a leading compound for development of drugs for hyperlipidemia. |
| 学科主题 | Cell Biology; Endocrinology & Metabolism |
| 类目[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | STEROL REGULATORY ELEMENT ; RECEPTOR LXR-ALPHA ; FEEDBACK-REGULATION ; LIPID-SYNTHESIS ; LDL RECEPTOR ; CHOLESTEROL ; MICE ; PROTEIN ; LIVER ; REDUCTASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286967400009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/725]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tang, JJ,Li, JG,Qi, W,et al. Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques[J]. CELL METABOLISM,2011,13(1):44-56. |
| APA | Tang, JJ.,Li, JG.,Qi, W.,Qiu, WW.,Li, PS.,...&Song, BL.(2011).Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques.CELL METABOLISM,13(1),44-56. |
| MLA | Tang, JJ,et al."Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques".CELL METABOLISM 13.1(2011):44-56. |
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