Derivation and characterization of human embryonic stem cell lines from the Chinese population
文献类型：期刊论文
| 作者 | Wu, Z; Li, H; Rao, LJ; He, LXZ; Bao, L; Liao, J; Cui, C; Zuo, ZY; Li, QA; Dai, HM |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2011 |
| 卷号 | 38期号:1页码:13-20 |
| 关键词 | Human embryonic stem cells Pluripotency Chinese population |
| 通讯作者 | Xiao, L (reprint author), Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China.,leixiao@zju.edu.cn ; changda0680@sina.com |
| 英文摘要 | Human embryonic stem cells (hESCs) can self-renew indefinitely and differentiate into all cell types in the human body. Therefore, they are valuable in regenerative medicine, human developmental biology and drug discovery. A number of hESC lines have been derived from the Chinese population, but limited of them are available for research purposes. Here we report the derivation and characterization of two hESC lines derived from human blastocysts of Chinese origin. These hESCs express alkaline phosphatase and hESC-specific markers, including Oct4, Nanog, SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81. They also have high levels of telomerase activity and normal karyotypes. These cells can form embryoid body in vitro and can be differentiated into all three germ layers in vivo by teratoma formation. The newly established hESCs will be distributed for research purposes. The availability of hESC lines from the Chinese population will facilitate studies on the differences in hESCs from different ethnic groups. |
| 学科主题 | Biochemistry & Molecular Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | HUMAN BLASTOCYSTS ; DIFFERENTIATION ; PLURIPOTENCY ; MAINTENANCE ; EXPRESSION ; NANOG ; EMBRYOTOXICITY ; IDENTIFICATION ; ESTABLISHMENT ; INTEGRATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287114300002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/731]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, Z,Li, H,Rao, LJ,et al. Derivation and characterization of human embryonic stem cell lines from the Chinese population[J]. JOURNAL OF GENETICS AND GENOMICS,2011,38(1):13-20. |
| APA | Wu, Z.,Li, H.,Rao, LJ.,He, LXZ.,Bao, L.,...&Tan, XJ.(2011).Derivation and characterization of human embryonic stem cell lines from the Chinese population.JOURNAL OF GENETICS AND GENOMICS,38(1),13-20. |
| MLA | Wu, Z,et al."Derivation and characterization of human embryonic stem cell lines from the Chinese population".JOURNAL OF GENETICS AND GENOMICS 38.1(2011):13-20. |
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