Negative Feedback Regulation of NF-kappa B Action by CITED2 in the Nucleus
文献类型：期刊论文
| 作者 | Lou, XW; Sun, SG; Chen, W; Zhou, Y; Huang, YF; Liu, X; Shan, YF; Wang, C |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 186期号:1页码:539-548 |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,shanyufei@sibs.ac.cn ; cwang01@sibs.ac.cn |
| 英文摘要 | NF-kappa B is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity of NF-kappa B is subjected to various spatial and temporal regulations. Bioinformatics analysis predicts that CITED2 is topologically close to NF-kappa B in the protein interaction networks. In this study, we show that ectopic expression or knockdown of CITED2 attenuates or potentiates, respectively, the expression of NF-kappa B-responsive genes. Mechanistically, CITED2 constitutively localizes inside the nucleus and interacts specifically with the coactivator p300. This prevents p65 from binding to p300, impairs p65 acetylation, and attenuates p65 binding to its cognate promoters. Furthermore, LPS induces CITED2 expression via NF-kappa B in macrophages. CITED2 sensitizes cells to TNF-alpha-induced apoptosis. Collectively, this study identifies CITED2 as a novel regulator of NF-kappa B in the nucleus, which reveals a negative feedback mechanism for NF-kappa B signaling. The Journal of Immunology, 2011, 186: 539-548. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | DEPENDENT GENE-EXPRESSION ; BINDING-PROTEIN ; INDUCED APOPTOSIS ; HEART DEVELOPMENT ; CELL-DEATH ; ACETYLATION ; COACTIVATOR ; PROMOTER ; P65 ; TRANSCRIPTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285688700061 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/732]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lou, XW,Sun, SG,Chen, W,et al. Negative Feedback Regulation of NF-kappa B Action by CITED2 in the Nucleus[J]. JOURNAL OF IMMUNOLOGY,2011,186(1):539-548. |
| APA | Lou, XW.,Sun, SG.,Chen, W.,Zhou, Y.,Huang, YF.,...&Wang, C.(2011).Negative Feedback Regulation of NF-kappa B Action by CITED2 in the Nucleus.JOURNAL OF IMMUNOLOGY,186(1),539-548. |
| MLA | Lou, XW,et al."Negative Feedback Regulation of NF-kappa B Action by CITED2 in the Nucleus".JOURNAL OF IMMUNOLOGY 186.1(2011):539-548. |
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