Backbone and side-chain H-1, N-15 and C-13 resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1
文献类型：期刊论文
| 作者 | Tse, HS; Hu, HY; Sze, KH |
| 刊名 | BIOMOLECULAR NMR ASSIGNMENTS
 |
| 出版日期 | 2011 |
| 卷号 | 5期号:2页码:165-168 |
| 关键词 | Ubiquitin carboxy-terminal hydrolase L1 Parkinson's disease Ubiquitin NMR spectroscopy Resonance assignment |
| 通讯作者 | Sze, KH (reprint author), Univ Hong Kong, Dept Chem, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.,tsehosum@hku.hk ; hyhu@sibs.ac.cn ; khsze@hku.hk |
| 英文摘要 | Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), also known as PGP9.5, is a protein of 223 amino acids. Although it was originally characterized as a deubiquitinating enzyme, recent studies indicate that it also functions as a ubiquitin (Ub) ligase and a mono-Ub stabilizer. It is highly abundant in brain, constituting up to 2% of total brain proteins. Down-regulation and extensive oxidative modification of UCH-L1 have been observed in the brains of Alzheimer's disease (AD) and Parkinson's disease (PD) patients. Mutations in the UCH-L1 gene have been reported to be linked to Parkinson's disease, in particular, the I93 M variant is associated with a higher susceptibility of PD in contrast to a higher protection against PD for the S18Y variant. Hence, the structure of UCH-L1 and the underlying effects of disease associated mutations on the structure and function of UCH-L1 are of considerable interest. Here, we report the NMR spectral assignments of the S18Y human UCH-L1 mutant with the aim to obtain better understanding about the risk of Parkinson's disease against structural and dynamical changes induced by this mutation on UCH-L1. |
| 学科主题 | Biophysics; Spectroscopy |
| 类目[WOS] | Biophysics ; Spectroscopy |
| 关键词[WOS] | PARKINSONS-DISEASE ; GENE ; UCH-L1 ; NEURON |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294559700010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/735]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tse, HS,Hu, HY,Sze, KH. Backbone and side-chain H-1, N-15 and C-13 resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1[J]. BIOMOLECULAR NMR ASSIGNMENTS,2011,5(2):165-168. |
| APA | Tse, HS,Hu, HY,&Sze, KH.(2011).Backbone and side-chain H-1, N-15 and C-13 resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1.BIOMOLECULAR NMR ASSIGNMENTS,5(2),165-168. |
| MLA | Tse, HS,et al."Backbone and side-chain H-1, N-15 and C-13 resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1".BIOMOLECULAR NMR ASSIGNMENTS 5.2(2011):165-168. |
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