Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway
文献类型：期刊论文
| 作者 | Jin, CY; Li, J; Green, CD; Yu, XM; Tang, X; Han, DL; Xian, B; Wang, D; Huang, XX; Cao, XW |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2011 |
| 卷号 | 14期号:2页码:161-172 |
| 通讯作者 | Han, JDJ (reprint author), Chinese Acad Sci, Max Planck Partner Inst Computat Biol, Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jdhan@picb.ac.cn |
| 英文摘要 | Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation in germlines, there is scant evidence implicating epigenetic regulations in aging. The insulin/IGF-1 signaling (IIS) pathway is a major life span regulatory pathway. Here, we show that progressive increases in gene expression and loss of H3K27me3 on IIS components are due, at least in part, to increased activity of the H3K27 demethylase UTX-1 during aging. RNAi of the utx-1 gene extended the mean life span of C. elegans by 30%, dependent on DAF-16 activity and not additive in daf-2 mutants. The loss of utx-1 increased H3K27me3 on the Igf1r/daf-2 gene and decreased IIS activity, leading to a more "naive" epigenetic state. Like stem cell reprogramming, our results suggest that reestablishment of epigenetic marks lost during aging might help "reset" the developmental age of animal cells. |
| 学科主题 | Cell Biology; Endocrinology & Metabolism |
| 类目[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | AGE-RELATED DISEASE ; CAENORHABDITIS-ELEGANS ; GENE-EXPRESSION ; TRANSCRIPTION FACTOR ; STEM-CELLS ; CHROMATIN IMMUNOPRECIPITATION ; H3K27 DEMETHYLASES ; FAMILY-MEMBER ; PI3 KINASE ; DAF-16 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000293606300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/736]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jin, CY,Li, J,Green, CD,et al. Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway[J]. CELL METABOLISM,2011,14(2):161-172. |
| APA | Jin, CY.,Li, J.,Green, CD.,Yu, XM.,Tang, X.,...&Han, JDJ.(2011).Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway.CELL METABOLISM,14(2),161-172. |
| MLA | Jin, CY,et al."Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway".CELL METABOLISM 14.2(2011):161-172. |
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