Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development
文献类型：期刊论文
| 作者 | Li, LY; Jing, NH |
| 刊名 | GENES
 |
| 出版日期 | 2011 |
| 卷号 | 2期号:2页码:298-312 |
| 关键词 | early embryonic development BMP FGF Nodal Wnt ESCs EpiSCs |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,lyli@sibs.ac.cn ; njing@sibs.ac.cn |
| 英文摘要 | Early embryonic development is a multi-step process that is intensively regulated by various signaling pathways. Because of the complexity of the embryo and the interactions between the germ layers, it is very difficult to fully understand how these signals regulate embryo patterning. Recently, pluripotent stem cell lines derived from different developmental stages have provided an in vitro system for investigating molecular mechanisms regulating cell fate decisions. In this review, we summarize the major functions of the BMP, FGF, Nodal and Wnt signaling pathways, which have well-established roles in vertebrate embryogenesis. Then, we highlight recent studies in pluripotent stem cells that have revealed the stage-specific roles of BMP, FGF and Nodal pathways during neural differentiation. These findings enhance our understanding of the stepwise regulation of embryo patterning by particular signaling pathways and provide new insight into the mechanisms underlying early embryonic development. |
| 学科主题 | Genetics & Heredity |
| 类目[WOS] | Genetics & Heredity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000209242000001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/739]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, LY,Jing, NH. Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development[J]. GENES,2011,2(2):298-312. |
| APA | Li, LY,&Jing, NH.(2011).Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development.GENES,2(2),298-312. |
| MLA | Li, LY,et al."Pluripotent Stem Cell Studies Elucidate the Underlying Mechanisms of Early Embryonic Development".GENES 2.2(2011):298-312. |
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