JAK2/STAT3 Pathway Is Involved in the Early Stage of Adipogenesis Through Regulating C/EBP beta Transcription
文献类型：期刊论文
| 作者 | Zhang, KM; Guo, W; Yang, Y; Wu, JR |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 112期号:2页码:488-497 |
| 关键词 | JAK2 STAT3 C/EBP beta ADIPOGENESIS |
| 通讯作者 | Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,wujr@sibs.ac.cn |
| 英文摘要 | Signal transducer and activator of transcription 3 (STAT3) was reported to be involved in adipogenesis. However, the regulating mechanism of STAT3 remains unclear. The present results showed that STAT3 was activated within 2-h adipogenic induction, in which the phosphorylated STAT3 translocated from cytoplasm to the nucleus. In addition, we detected Janus kinase2 (JAK2) acted upstream of the STAT3 activation at the early stage of adipogenesis. Accordingly, the JAK2 inhibitor AG490 and siRNAs led to the partial inhibition of the STAT3 activation, and the inhibition of 3T3-L1 adipocyte differentiation. Furthermore, the results based on lueiferase, chromatin immunoprecipitation, and gel shift approaches indicated that STAT3 could regulate the transcription of C/EBP beta by binding the distal region of C/EBP beta promoter at the early stage of adipogenesis. Collectively, our findings reveal that JAK2/STAT3 pathway is involved in the early stage of 3T3-L1 adipocyte differentiation though regulating the C/EBP beta transcription. J. Cell. Biochem. 112: 488-497, 2011. (C) 2010 Wiley-Liss, Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | ADIPOSE CELL LINE ; ADIPOCYTE DIFFERENTIATION ; GENE-EXPRESSION ; SIGNAL TRANSDUCER ; 3T3-L1 CELLS ; PROTEIN ; STATS ; PROLIFERATION ; CONVERSION ; INHIBITOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287071900017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/744]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, KM,Guo, W,Yang, Y,et al. JAK2/STAT3 Pathway Is Involved in the Early Stage of Adipogenesis Through Regulating C/EBP beta Transcription[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2011,112(2):488-497. |
| APA | Zhang, KM,Guo, W,Yang, Y,&Wu, JR.(2011).JAK2/STAT3 Pathway Is Involved in the Early Stage of Adipogenesis Through Regulating C/EBP beta Transcription.JOURNAL OF CELLULAR BIOCHEMISTRY,112(2),488-497. |
| MLA | Zhang, KM,et al."JAK2/STAT3 Pathway Is Involved in the Early Stage of Adipogenesis Through Regulating C/EBP beta Transcription".JOURNAL OF CELLULAR BIOCHEMISTRY 112.2(2011):488-497. |
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