FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
文献类型：期刊论文
| 作者 | Tang, YN; Shu, GW; Yuan, XW; Jing, NH; Song, JG |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:2页码:316-326 |
| 关键词 | FOXA2 EMT TGF-beta 1 lung tumors slug |
| 通讯作者 | Song, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn |
| 英文摘要 | The forkhead box transcription factor A2 (FOXA2) is an important regulator in animal development and body homeostasis. However, whether FOXA2 is involved in transforming growth factor beta 1 (TGF-beta 1)-mediated epithelial-to-mesenchymal transition (EMT) and tumor metastasis remains unknown. The present study showed that in human lung cancer cell lines, the abundance of FOXA2 positively correlates with epithelial phenotypes and negatively correlates with the mesenchymal phenotypes of cells, and TGF-beta 1 treatment decreased FOXA2 protein level. Consistently, knockdown of FOXA2 promoted EMT and invasion of lung cancer cells, whereas overexpression of FOXA2 reduced the invasion and suppressed TGF-beta 1-induced EMT. In addition, knockdown of FOXA2 induced slug expression, and ectopic expression of FOXA2 inhibited slug transcription. Furthermore, we identified that FOXA2 can bind to slug promoter through a conserved binding site, and that the DNA-binding region and transactivation region II of FOXA2 are required for repression of the slug promoter. These data demonstrate that FOXA2 functions as a suppressor of tumor metastasis by inhibition of EMT. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | TRANSCRIPTIONAL ACTIVATION ; GENE FAMILY ; EXPRESSION ; PROTEIN ; GROWTH ; PROGRESSION ; HOMEOSTASIS ; APOPTOSIS ; DOMAINS ; SNAIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286922200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/750]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tang, YN,Shu, GW,Yuan, XW,et al. FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers[J]. CELL RESEARCH,2011,21(2):316-326. |
| APA | Tang, YN,Shu, GW,Yuan, XW,Jing, NH,&Song, JG.(2011).FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers.CELL RESEARCH,21(2),316-326. |
| MLA | Tang, YN,et al."FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers".CELL RESEARCH 21.2(2011):316-326. |
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