ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)
文献类型：期刊论文
| 作者 | Li, ZH; Zhang, YA; Liu, ZD; Wu, XD; Zheng, YH; Tao, ZY; Mao, KR; Wang, J; Lin, GM; Tian, L |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 12期号:2页码:178-U95 |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai, Peoples R China.,bsun@sibs.ac.cn |
| 英文摘要 | Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | MATRIX PROTEIN-1 ECM1 ; SPHINGOSINE 1-PHOSPHATE RECEPTORS ; T-CELLS ; L-SELECTIN ; SPHINGOSINE-1-PHOSPHATE ; TRAFFICKING ; MIGRATION ; ORGANS ; MOUSE ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286378400012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/751]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, ZH,Zhang, YA,Liu, ZD,et al. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)[J]. NATURE IMMUNOLOGY,2011,12(2):178-U95. |
| APA | Li, ZH.,Zhang, YA.,Liu, ZD.,Wu, XD.,Zheng, YH.,...&Sun, B.(2011).ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).NATURE IMMUNOLOGY,12(2),178-U95. |
| MLA | Li, ZH,et al."ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)".NATURE IMMUNOLOGY 12.2(2011):178-U95. |
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