LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor
文献类型：期刊论文
| 作者 | Gao, YJ; Ge, GX; Ji, HB |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2011 |
| 卷号 | 2期号:2页码:99-107 |
| 关键词 | liver kinase B1 lung cancer tumor suppressor |
| 通讯作者 | Ji, HB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,gxge@sibs.ac.cn |
| 英文摘要 | Lung cancer is featured with high mortality, with a 15% five-year survival rate worldwide. Genetic alterations, such as loss of function of tumor suppressor genes, frequently contribute to lung cancer initiation, progression and metastasis. Liver kinase B1 (LKB1), as a serine/threonine kinase and tumor suppressor, is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process, especially lung cancer progression and metastasis. This review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis, emphasizing on LKB1 downstream signaling pathways and biological functions. We will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | PEUTZ-JEGHERS-SYNDROME ; ACTIVATED PROTEIN-KINASE ; HEMATOPOIETIC STEM-CELLS ; CANCER PROGRESSION ; SOMATIC MUTATIONS ; KNOCKOUT MICE ; GENE ; ADENOCARCINOMAS ; LKB1/STK11 ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310519500004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/755]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gao, YJ,Ge, GX,Ji, HB. LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor[J]. PROTEIN & CELL,2011,2(2):99-107. |
| APA | Gao, YJ,Ge, GX,&Ji, HB.(2011).LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.PROTEIN & CELL,2(2),99-107. |
| MLA | Gao, YJ,et al."LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor".PROTEIN & CELL 2.2(2011):99-107. |
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