Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice
文献类型：期刊论文
| 作者 | Sun, RL; Wang, HY; Yang, XY; Sheng, ZJ; Li, LM; Wang, L; Wang, ZG; Fei, J |
| 刊名 | GENETICS AND MOLECULAR RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 10期号:4页码:3712-3721 |
| 关键词 | IL-1 beta IL-6 LPS Zinc finger protein 191 |
| 通讯作者 | Fei, J (reprint author), Shanghai Res Ctr Model Organisms, Shanghai, Peoples R China.,jfei@tongji.edu.cn |
| 英文摘要 | Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Kruppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan. Three hundred and fifty-five putative target genes were identified, which were enriched into the pathways of immune response according to the pathway analysis. These targets indicated that Zfp191 may function as a mediator of the immune response. This was verified in mice heterozygous for Zfp191 (Zfp191(+/-)) using a lipopolysaccharide (LPS)-induced endotoxic shock model. After LPS injection, Zfp191(+/-) mice produced significantly less IL-1 beta and IL-6 compared to wild-type mice and were resistant to LPS-induced endotoxic shock. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during LPS-induced endotoxic shock. |
| 学科主题 | Biochemistry & Molecular Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | ZINC-FINGER TRANSCRIPTION ; ACTIVATED PROTEIN-KINASE ; EMBRYONIC-DEVELOPMENT ; SCAN DOMAIN ; SEPSIS ; IDENTIFICATION ; EXPRESSION ; REVEALS ; MECHANISMS ; CLONING |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300617600144 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/788]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, RL,Wang, HY,Yang, XY,et al. Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice[J]. GENETICS AND MOLECULAR RESEARCH,2011,10(4):3712-3721. |
| APA | Sun, RL.,Wang, HY.,Yang, XY.,Sheng, ZJ.,Li, LM.,...&Fei, J.(2011).Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice.GENETICS AND MOLECULAR RESEARCH,10(4),3712-3721. |
| MLA | Sun, RL,et al."Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice".GENETICS AND MOLECULAR RESEARCH 10.4(2011):3712-3721. |
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