Differential response of multiple zebrafish hepatic F-box protein genes to 17 alpha-ethinylestradiol treatment
文献类型：期刊论文
| 作者 | Zheng, HP; Li, SF; Wu, ZL; Zhang, YB; Hu, SN; Yan, YC; Li, YP |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| 出版日期 | 2011 |
| 卷号 | 23期号:4页码:664-670 |
| 关键词 | estrogen 17 alpha-ethinylestradiol F-box hepatic tumor zebrafish |
| 通讯作者 | Li, YP (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China.,gt_19992000@yahoo.com.cn ; happylishifeng@163.com ; yipingli@sibs.ac.cn |
| 英文摘要 | Estrogens are accumulating in environment and their effects on a variety of reproductive processes and tumorigenesis were reported by previous study, but the mechanism of estrogen promoting neoplasia was still not clear. F-box protein (FBP) is the component of E3 ubiquitin ligase which takes part in a variety of key biological processes. In this study, using mature male zebrafish, which are more sensitive to estrogen treatment, we examined influence of 17 alpha-ethinylestradiol (EE2) exposure on the expression of a series of hepatic FBP genes, which take part in a variety of biological processes, including tumorigenesis. The influence of EE2 on the expression of hepatic mRNA concentrations of FBP genes were quantified based on the expression of the optimal internal control gene in male zebrafish after 7-day exposure to EE2, from a low-dose concentration (1 ng/L) to environmentally relevant concentrations (10, 100 ng/L). Our results showed that EE2 exposure reduced the expression of fbxl14a, fbxl14b, fbxo25 and beta-TRCP2b, but enchanced the expression of skp2. While the alterations in fbxl2, fbxw7, fbxo9, beta-TRCP2a, fbxl18 and fbxo45 mRNA levels were not observed after EE2 exposure. Thus, our results showed that the expression of hepatic FBP genes exhibited differentially in male zebrafish exposed EE2. The changes of the expression level of FBP genes induced by EE2 may be an important clue to elucidate the correlations of estrogen and hepatic tumors. |
| 学科主题 | Environmental Sciences & Ecology |
| 类目[WOS] | Environmental Sciences |
| 关键词[WOS] | ENDOCRINE-DISRUPTING CHEMICALS ; ESTROGEN-RECEPTOR ; DANIO-RERIO ; UBIQUITIN LIGASES ; RAINBOW-TROUT ; CELL-CYCLE ; ER-ALPHA ; EXPRESSION ; CANCER ; LIVER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289871300019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/789]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, HP,Li, SF,Wu, ZL,et al. Differential response of multiple zebrafish hepatic F-box protein genes to 17 alpha-ethinylestradiol treatment[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2011,23(4):664-670. |
| APA | Zheng, HP.,Li, SF.,Wu, ZL.,Zhang, YB.,Hu, SN.,...&Li, YP.(2011).Differential response of multiple zebrafish hepatic F-box protein genes to 17 alpha-ethinylestradiol treatment.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,23(4),664-670. |
| MLA | Zheng, HP,et al."Differential response of multiple zebrafish hepatic F-box protein genes to 17 alpha-ethinylestradiol treatment".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 23.4(2011):664-670. |
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