Induction of dopaminergic neuronal-like cells from CD44(+) human amniotic fluids that are ameliorative to behavioral recovery in a Parkinson's disease rat model
文献类型：期刊论文
| 作者 | Liu, T; Guo, LH; Liu, ZX; Huang, YY; Cheng, WW |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
 |
| 出版日期 | 2011 |
| 卷号 | 28期号:5页码:745-752 |
| 关键词 | cells transplantation dopaminergic neurons human amniotic fluid cells Parkinson's disease rat model |
| 通讯作者 | Cheng, WW (reprint author), Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Shanghai 200030, Peoples R China.,liute79@yahoo.com |
| 英文摘要 | Parkinson's disease (PD) is a common age-associated neurodegenerative disorder. To date, stem cell transplantation therapy has been developed to replace lost or damaged neural cells in PD patients, in whom dopaminergic neuron cells are lost. Here, we show that CD44(+) human amniotic fluid cells (HuAFCs) can be induced to become functional dopaminergic neuronal-like cells in vitro. Furthermore, when CD44(+) or CD44(-) HuAFCs were transplanted into 6-hydroxydopamine (6-OHDA)-treated PD rats, the results indicated that CD44(+) HuAFCs expressed multiple dopaminergic neuron cell markers and were ameliorative to behavioral recovery in PD rats after induction both in vitro and in vivo. CD44(-) HuAFCs did not fully differentiate into dopaminergic neuronal-like cells. When compared with CD44(-) HuAFCs, CD44(+) HuAFCs showed increased activity in regeneration of dopaminergic neuron cell-like cells, increased migration distances, and improvement of animal behavior in the PD rat model. Therefore, CD44(+) HuAFCs could be a source of dopaminergic neuronal-like cells with a potential use in cell-replacement therapy for PD. |
| 学科主题 | Research & Experimental Medicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 关键词[WOS] | MESENCHYMAL STEM-CELLS ; NEUROTROPHIN-3 GENE ; IN-VITRO ; DIFFERENTIATION ; TRANSPLANTATION ; PLURIPOTENCY ; INJURY ; LINES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295422600010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/795]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, T,Guo, LH,Liu, ZX,et al. Induction of dopaminergic neuronal-like cells from CD44(+) human amniotic fluids that are ameliorative to behavioral recovery in a Parkinson's disease rat model[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2011,28(5):745-752. |
| APA | Liu, T,Guo, LH,Liu, ZX,Huang, YY,&Cheng, WW.(2011).Induction of dopaminergic neuronal-like cells from CD44(+) human amniotic fluids that are ameliorative to behavioral recovery in a Parkinson's disease rat model.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,28(5),745-752. |
| MLA | Liu, T,et al."Induction of dopaminergic neuronal-like cells from CD44(+) human amniotic fluids that are ameliorative to behavioral recovery in a Parkinson's disease rat model".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 28.5(2011):745-752. |
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