Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase
文献类型：期刊论文
| 作者 | Li, KC; Zhang, FX; Li, CL; Wang, F; Yu, MY; Zhong, YQ; Zhang, KH; Lu, YJ; Wang, QO; Ma, XL |
| 刊名 | NEURON
 |
| 出版日期 | 2011 |
| 卷号 | 69期号:5页码:974-987 |
| 通讯作者 | Gao, XA (reprint author), Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Peoples R China.,gaoxiang@nju.edu.cn ; xu.zhang@ion.ac.cn |
| 英文摘要 | Excitatory synaptic transmission is modulated by inhibitory neurotransmitters and neuromodulators. We found that the synaptic transmission of somatic sensory afferents can be rapidly regulated by a presynaptically secreted protein, follistatin-like 1 (FSTL1), which serves as a direct activator of Na+,K+-ATPase (NKA). The FSTL1 protein is highly expressed in small-diameter neurons of the dorsal root ganglion (DRG). It is transported to axon terminals via small translucent vesicles and secreted in both spontaneous and depolarization-induced manners. Biochemical assays showed that FSTL1 binds to the alpha 1 subunit of NKA and elevates NKA activity. Extracellular FSTL1 induced membrane hyperpolarization in cultured cells and inhibited afferent synaptic transmission in spinal cord slices by activating NKA. Genetic deletion of FSTL1 in small DRG neurons of mice resulted in enhanced afferent synaptic transmission and sensory hypersensitivity, which could be reduced by intrathecally applied FSTL1 protein. Thus, FSTL1-dependent activation of NKA regulates the threshold of somatic sensation. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | DORSAL-ROOT GANGLIA ; PERIPHERAL NERVOUS-SYSTEM ; SYNAPTIC VESICLE ; SPINAL-CORD ; NA+/K+ PUMP ; NEURONS ; RAT ; PROTEIN ; EXPRESSION ; ISOFORMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288736500014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/814]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, KC,Zhang, FX,Li, CL,et al. Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase[J]. NEURON,2011,69(5):974-987. |
| APA | Li, KC.,Zhang, FX.,Li, CL.,Wang, F.,Yu, MY.,...&Zhang, X.(2011).Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase.NEURON,69(5),974-987. |
| MLA | Li, KC,et al."Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase".NEURON 69.5(2011):974-987. |
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