Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state
文献类型：期刊论文
| 作者 | Wang, HF; Song, WJ; Huang, GH; Zhou, Z; Ding, YF; Chen, JY |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 585期号:5页码:797-802 |
| 关键词 | Zcf37 Regulator White-opaque switching Candida albicans |
| 通讯作者 | Chen, JY (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, SIBS, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jychen@sibs.ac.cn |
| 英文摘要 | Candida albicans, the most prevalent human fungal pathogen, can switch stochastically between white and opaque phases. In this study, we identified Zcf37, a zinc finger protein, as a new regulator of white-opaque switching. Deletion of ZCF37 increased white-to-opaque switching frequency and stabilized the opaque state. Overexpression of ZCF37 promoted conversion of opaque cells to white phase, but needed existence of Efg1, a key regulator required for maintenance of the white state. Deletion of EFG1 abolished the effect of ectopically expressed Zcf37 on opaque-to-white switching, whereas ectopic expression of EFG1 promoted white cell formation without presence of Zcf37. Our results suggest that Zcf37 acts as an activator of white cell formation and a repressor of opaque state and functions upstream of Efg1. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | HYPHAL DEVELOPMENT ; MORPHOGENETIC REGULATOR ; TRANSCRIPTION FACTOR ; FILAMENTOUS GROWTH ; YEAST ; EXPRESSION ; VIRULENCE ; FAMILY ; LOOP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287960900014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/815]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, HF,Song, WJ,Huang, GH,et al. Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state[J]. FEBS LETTERS,2011,585(5):797-802. |
| APA | Wang, HF,Song, WJ,Huang, GH,Zhou, Z,Ding, YF,&Chen, JY.(2011).Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state.FEBS LETTERS,585(5),797-802. |
| MLA | Wang, HF,et al."Candida albicans Zcf37, a zinc finger protein, is required for stabilization of the white state".FEBS LETTERS 585.5(2011):797-802. |
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