A novel conotoxin, qc16a, with a unique cysteine framework and folding
文献类型：期刊论文
| 作者 | Ye, MY; Hong, J; Zhou, M; Huang, LJ; Shao, XX; Yang, YS; Sigworth, FJ; Chi, CW; Lin, DH; Wang, CG |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:6页码:1159-1165 |
| 关键词 | Conotoxin Conus quercinus Disulfide connectivity Mutation NMR Electrophysiology |
| 通讯作者 | Lin, DH (reprint author), Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China.,dhlin@xmu.edu.cn ; chunguangwang@tongji.edu.cn |
| 英文摘要 | A novel conotoxin, qc16a, was identified from the venom of vermivorous Conus quercinus. qc16a has only 11 amino acid residues, DCQPCGHNVCC, with a unique cysteine pattern. Its disulfide connectivity was determined to be I-IV, II-III. The NMR structure shows that qc16a adopts a ribbon conformation with a simple beta-turn motif formed by residues Gly6, His7 and Asn8. qc16a causes depression symptom in mice when injected intracranially. Point mutation results showed that Asp1, His7 and Asn8 are all essential for the activity of qc16a. Electrophysiologically, qc16a has no strong effect on the whole-cell currents of neurons and the currents of Drosophila Shaker channels, human BK channels and Na(V)1.7 channels. Its specific target still remains to be identified. (C) 2011 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 关键词[WOS] | NMR SYSTEM ; CONUS ; CRYSTALLOGRAPHY ; SUPERFAMILY ; TRANSPORTER ; PEPTIDES ; VENOM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292586200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/821]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ye, MY,Hong, J,Zhou, M,et al. A novel conotoxin, qc16a, with a unique cysteine framework and folding[J]. PEPTIDES,2011,32(6):1159-1165. |
| APA | Ye, MY.,Hong, J.,Zhou, M.,Huang, LJ.,Shao, XX.,...&Wang, CG.(2011).A novel conotoxin, qc16a, with a unique cysteine framework and folding.PEPTIDES,32(6),1159-1165. |
| MLA | Ye, MY,et al."A novel conotoxin, qc16a, with a unique cysteine framework and folding".PEPTIDES 32.6(2011):1159-1165. |
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