Est1 Protects Telomeres and Inhibits Subtelomeric Y '-Element Recombination
文献类型：期刊论文
| 作者 | Tong, XJ; Li, QJ; Duan, YM; Liu, NN; Zhang, ML; Zhou, JQ |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 31期号:6页码:1263-1274 |
| 通讯作者 | Zhou, JQ (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci,Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,jqzhou@sibs.ac.cn |
| 英文摘要 | In the budding yeast Saccharomyces cerevisiae, the structure and function of telomeres are maintained by binding proteins, such as Cdc13-Stn1-Ten1 (CST), Yku, and the telomerase complex. Like CST and Yku, telomerase also plays a role in telomere protection or capping. Unlike CST and Yku, however, the underlying molecular mechanism of telomerase-mediated telomere protection remains unclear. In this study, we employed both the CDC13-EST1 fusion gene and the separation-of-function allele est1-D514A to elucidate that Est1 provided a telomere protection pathway that was independent of both the CST and Yku pathways. Est1's ability to convert single-stranded telomeric DNA into a G quadruplex was required for telomerase-mediated telomere protection function. Additionally, Est1 maintained the integrity of telomeres by suppressing the recombination of subtelomeric Y' elements. Our results demonstrate that one major functional role that Est1 brings to the telomerase complex is the capping or protection of telomeres. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | DNA-BINDING PROTEIN ; SINGLE-STRANDED-DNA ; SACCHAROMYCES-CEREVISIAE TELOMERASE ; YEAST TELOMERASE ; CATALYTIC SUBUNIT ; LENGTH REGULATION ; BOUND TELOMERASE ; EFFICIENT BYPASS ; END PROTECTION ; BUDDING YEAST |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287694700013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/828]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tong, XJ,Li, QJ,Duan, YM,et al. Est1 Protects Telomeres and Inhibits Subtelomeric Y '-Element Recombination[J]. MOLECULAR AND CELLULAR BIOLOGY,2011,31(6):1263-1274. |
| APA | Tong, XJ,Li, QJ,Duan, YM,Liu, NN,Zhang, ML,&Zhou, JQ.(2011).Est1 Protects Telomeres and Inhibits Subtelomeric Y '-Element Recombination.MOLECULAR AND CELLULAR BIOLOGY,31(6),1263-1274. |
| MLA | Tong, XJ,et al."Est1 Protects Telomeres and Inhibits Subtelomeric Y '-Element Recombination".MOLECULAR AND CELLULAR BIOLOGY 31.6(2011):1263-1274. |
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