Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1
文献类型：期刊论文
| 作者 | Ren, JK; Chen, Z; Zhang, W; Li, LM; Sun, RL; Deng, CG; Fei, ZL; Sheng, ZJ; Wang, L; Sun, X |
| 刊名 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:7页码:691-698 |
| 关键词 | Fat mass Insulin resistance Obesity Pancreatic lipase-related protein 1 Knockout |
| 通讯作者 | Fei, J (reprint author), Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China.,jfei@tongji.edu.cn |
| 英文摘要 | Pancreatic triglyceride lipase (ER) and its cofactor, colipase, are required for efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize two pancreatic lipase-related proteins (PLRP1 and PLRP2), which have a high degree of sequence and structural homology with PTL The lipase activity of PLRP2 has been confirmed, whereas no known triglyceride lipase activity has been detected with PLRP1 up to now. To explore the biological functions of PLRP1 in vivo, we generated Plrp1 knockout (KO) mice in our laboratory. Here we show that the Plrp1 KO mice displayed mature-onset obesity with increased fat mass, impaired glucose clearance and the resultant insulin resistance. When fed on high-fat (HF) diet, the Plrp1 KO mice exhibited an increased weight gain, fat mass and severe insulin resistance compared with wild-type mice. Pancreatic juice extracted from Plrp1 KO mice had greater ability to hydrolyze triglyceride than that from the wild-type littermates. We propose that PLRP1 may function as a metabolic inhibitor in vivo of PLT-colipase-mediated dietary triglyceride digestion and provides potential anti-obesity targets for developing new drugs. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Nutrition & Dietetics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 关键词[WOS] | IN-VITRO LIPOLYSIS ; CO-LIPASE ; DIGESTIVE LIPASES ; BILE-SALTS ; COLIPASE ; OBESITY ; TAURODEOXYCHOLATE ; SUBSTRATE ; MECHANISM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292354700011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/834]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ren, JK,Chen, Z,Zhang, W,et al. Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2011,22(7):691-698. |
| APA | Ren, JK.,Chen, Z.,Zhang, W.,Li, LM.,Sun, RL.,...&Fei, J.(2011).Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,22(7),691-698. |
| MLA | Ren, JK,et al."Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 22.7(2011):691-698. |
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