Current understanding of Th2 cell differentiation and function
文献类型：期刊论文
| 作者 | Li, ZH; Zhang, Y; Sun, B |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2011 |
| 卷号 | 2期号:8页码:604-611 |
| 关键词 | type 2 helper T cell (Th2) asthma IL-9 secreting T cell (Th9) T follicular helper cell |
| 通讯作者 | Sun, B (reprint author), Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn |
| 英文摘要 | Helper T cell (Th) has been identified as a critical immune cell for regulating immune response since 1980s. The type 2 helper T cell (Th2), characterized by the production of interleukin-4 (IL-4), IL-5 and IL-13, plays a critical role in immune response against helminths invading cutaneous or mucosal sites. It also has a functional role in the pathophysiology of allergic diseases such as asthma and allergic diarrhea. Currently, most studies have shed light on Th2 cell function and behavior in specific diseases, such as asthma and helminthes inflammation, but not on Th2 cell itself and its differentiation. Based on different cytokines and specific behavior in recent research, Th2 cell is also regarded as new subtypes of T cell, such as IL-9 secreting T cell (Th9) and CXCR5(+) T follicular helper cells. Here, we will discuss the latest view of Th2 cell towards their function and the involvement of Th2 cell in diseases. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | FOLLICULAR-HELPER-CELLS ; CD4(+) T-CELLS ; INTERFERON-REGULATORY FACTOR-4 ; CXC CHEMOKINE RECEPTOR-5 ; ANTIGEN-PRESENTING CELLS ; TRANSCRIPTION FACTOR ; LINEAGE COMMITMENT ; GERMINAL-CENTERS ; GENE-EXPRESSION ; TGF-BETA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310521900002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/844]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, ZH,Zhang, Y,Sun, B. Current understanding of Th2 cell differentiation and function[J]. PROTEIN & CELL,2011,2(8):604-611. |
| APA | Li, ZH,Zhang, Y,&Sun, B.(2011).Current understanding of Th2 cell differentiation and function.PROTEIN & CELL,2(8),604-611. |
| MLA | Li, ZH,et al."Current understanding of Th2 cell differentiation and function".PROTEIN & CELL 2.8(2011):604-611. |
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