UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation
文献类型：期刊论文
| 作者 | Huang, YF; Chen, LA; Zhou, Y; Liu, H; Yang, JQ; Liu, ZG; Wang, C |
| 刊名 | MOLECULAR BIOLOGY OF THE CELL
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:8页码:1389-1397 |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,zgliu@box-z.nih.gov ; cwang01@sibs.ac.cn |
| 英文摘要 | Proteins that directly regulate tumor necrosis factor (TNF) signaling have critical roles in determining cell death and survival. Previously we characterized ubiquitously expressed transcript (UXT)-V2 as a novel transcriptional cofactor to regulate nuclear factor-kappa B in the nucleus. Here we report that another splicing isoform of UXT, UXT-V1, localizes in cytoplasm and regulates TNF-induced apoptosis. UXT-V1 knockdown cells are hypersensitive to TNF-induced apoptosis. We demonstrated that UXT-V1 is a new component of TNF receptor signaling complex. We found that UXT-V1 binds to TNF receptor-associated factor 2 and prevents TNF receptor-associated death domain protein from recruiting Fas-associated protein with death domain. More importantly, UXT-V1 is a short-half-life protein, the degradation of which facilitates the formation of the apoptotic receptor complex II in response to TNF treatment. This study demonstrates that UXT-V1 is a novel regulator of TNF-induced apoptosis and sheds new light on the underlying molecular mechanism of this process. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | NF-KAPPA-B ; ALPHA-INDUCED APOPTOSIS ; C-FLIP ; CASPASE-8 ACTIVATION ; STRUCTURAL BASIS ; KINASE RIP ; DEATH ; INHIBITION ; INDUCTION ; PATHWAYS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289558600023 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/845]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, YF,Chen, LA,Zhou, Y,et al. UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation[J]. MOLECULAR BIOLOGY OF THE CELL,2011,22(8):1389-1397. |
| APA | Huang, YF.,Chen, LA.,Zhou, Y.,Liu, H.,Yang, JQ.,...&Wang, C.(2011).UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.MOLECULAR BIOLOGY OF THE CELL,22(8),1389-1397. |
| MLA | Huang, YF,et al."UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation".MOLECULAR BIOLOGY OF THE CELL 22.8(2011):1389-1397. |
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