A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus
文献类型：期刊论文
| 作者 | Zhuang, XX; Sun, YZ; Ling, ZY; Dong, QX; Zhu, JY; Tang, LN; Zhou, YY; Ji, YY; Tian, L; Lin, GM |
| 刊名 | COMPTES RENDUS CHIMIE
 |
| 出版日期 | 2011 |
| 卷号 | 14期号:9页码:826-830 |
| 关键词 | Immunoassays Immunology Proteins Antigens Antibodies |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai 200025, Peoples R China.,cbian@sibs.ac.cn ; bsun@sibs.ac.cn |
| 英文摘要 | Monoclonal antibodies are needed for the development of effective, accurate and sensitive immunoassays against the H5N1 avian influenza. Here we report the generation of monoclonal antibodies targeting Escherichia coli expressed hemagglutinin of HA1 domain from H5N1 influenza virus. The monoclonal antibodies can be used to establish a sandwich ELISA assay that is able to detect HA from H5 subtype virus lysate but not from H9 subtype. A subtype-conserved new epitope was also identified which is located between the amino acid residues N80 to A99. This work would be helpful for the development of a diagnosis kit for the H5N1 avian influenza. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 关键词[WOS] | MOLECULE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296953500006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/847]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhuang, XX,Sun, YZ,Ling, ZY,et al. A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus[J]. COMPTES RENDUS CHIMIE,2011,14(9):826-830. |
| APA | Zhuang, XX.,Sun, YZ.,Ling, ZY.,Dong, QX.,Zhu, JY.,...&Sun, B.(2011).A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus.COMPTES RENDUS CHIMIE,14(9),826-830. |
| MLA | Zhuang, XX,et al."A detective monoclonal antibody recognized conserved epitope of hemagglutinin from H5N1 influenza virus".COMPTES RENDUS CHIMIE 14.9(2011):826-830. |
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