MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11
文献类型：期刊论文
| 作者 | Liu, XX; Li, XJ; Zhang, B; Liang, YJ; Zhou, CX; Cao, DX; He, M; Chen, GQ; He, JR; Zhao, Q |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 585期号:9页码:1363-1367 |
| 关键词 | miR-26b SLC7A11 Apoptosis Breast cancer |
| 通讯作者 | He, JR (reprint author), Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis,Natl Minist, 280 Chong Qing S Rd, Shanghai 200025, Peoples R China.,HEJRONG@hotmail.com ; qzhao@shsmu.edu.cn |
| 英文摘要 | MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. Here, we show that miR-26b, which is down-regulated in human breast cancer specimens and cell lines, impairs viability and triggers apoptosis of human breast cancer MCF7 cells. SLC7A11 is identified as a direct target of miR-26b and its expression is remarkably increased in both breast cancer cell lines and clinical samples. Furthermore, SLC7A11 silence mimics miR-26b-aroused viability impairment and apoptosis in MCF7 cells. Our studies reveal a protective role of miR-26b in the molecular etiology of human breast cancer by promoting apoptosis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | LIVER-CANCER ; EXPRESSION ; CYSTINE ; RESISTANCE ; TRANSPORT ; LINES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290248300018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/851]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, XX,Li, XJ,Zhang, B,et al. MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11[J]. FEBS LETTERS,2011,585(9):1363-1367. |
| APA | Liu, XX.,Li, XJ.,Zhang, B.,Liang, YJ.,Zhou, CX.,...&Zhao, Q.(2011).MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11.FEBS LETTERS,585(9),1363-1367. |
| MLA | Liu, XX,et al."MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11".FEBS LETTERS 585.9(2011):1363-1367. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。